CFL1 and LIMK1

Data Source:
HPRD (in vitro, in vivo)

		CFL1	LIMK1
Description		cofilin 1	LIM domain kinase 1
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Focal Adhesion Actin Cytoskeleton Membrane Nuclear Matrix Lamellipodium Lamellipodium Membrane Vesicle Ruffle Membrane Extracellular Exosome	Nucleus Cytoplasm Cytosol Cytoskeleton Nuclear Speck Lamellipodium Neuron Projection
	Molecular Function	Protein Binding Actin Filament Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Heat Shock Protein Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Cytoskeleton Organization Rho Protein Signal Transduction Response To Virus Viral Process Regulation Of Cell Morphogenesis Actin Cytoskeleton Organization Actin Filament Depolymerization Actin Filament Fragmentation Interleukin-12-mediated Signaling Pathway Positive Regulation Of Embryonic Development Negative Regulation Of Apoptotic Process Positive Regulation By Host Of Viral Process Cell Motility Actin Filament Severing Establishment Of Spindle Localization Regulation Of Dendritic Spine Morphogenesis	Protein Phosphorylation Signal Transduction Rho Protein Signal Transduction Nervous System Development Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Bundle Assembly Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Axon Extension Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Stress Fiber Assembly
Pathways		Platelet degranulation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling Sema3A PAK dependent Axon repulsion RHO GTPases Activate ROCKs Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling Sema3A PAK dependent Axon repulsion Sema3A PAK dependent Axon repulsion Sema4D induced cell migration and growth-cone collapse RHO GTPases Activate ROCKs RHO GTPases activate PAKs
Drugs		Dodecyldimethylamine N-oxide Copper Artenimol	Dabrafenib Fostamatinib
Diseases
GWAS		Acne (severe) ( 24927181) Basal cell carcinoma ( 31174203) Breast cancer ( 23535729) DNA methylation (variation) ( 23725790) Keratinocyte cancer (MTAG) ( 31174203) Neutrophil count ( 32888494) Platelet count ( 32888494) Psoriasis ( 28537254) White blood cell count ( 32888494)	Pulse pressure ( 30224653) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		43 interacting genes: ACTA1 ACTA2 ACTB ACTC1 ACTG1 APP ATP1A1 ATXN1 CFL2 CLCN5 EGFR ERBB2 ERBB3 ERBB4 ESR1 HSPH1 LIMK1 LIMK2 MAPK6 MAPK8IP2 MYCBP NRK POT1 PSEN1 PTEN RAD21 RPS6KA1 SLC2A4 SRC SSH1 SSH2 SSH3 TAB1 TERF1 TESK1 TESK2 TPI1 TRIM15 UCHL5 WDR1 YWHAG YWHAQ YWHAZ	30 interacting genes: ABCA1 APP ARRB1 ARRB2 BMPR2 C22orf15 CDC42BPA CDKN1C CFL1 CFL2 FBXO7 H1-1 LATS1 LIMK2 MAPK14 MAPKAPK2 MBP MFHAS1 NRG1 PAK1 PAK2 PAK4 PAK6 PXN RLIM ROCK1 SRPK1 SSH3 WASHC1 YWHAZ
Entrez ID		1072	3984
HPRD ID		03261	03210
Ensembl ID		ENSG00000172757	ENSG00000106683
Uniprot IDs		P23528 V9HWI5	P53667
PDB IDs		1Q8G 1Q8X 3J0S 4BEX 5HVK 5L6W 6UBY 6UC0 6UC4 6VAO	3S95 5HVJ 5HVK 5L6W 5NXC 6WLY
Enriched GO Terms of Interacting Partners?
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