SSH1 and CFL2

Data Source:
HPRD (in vivo)

		SSH1	CFL2
Description		slingshot protein phosphatase 1	cofilin 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Lamellipodium Growth Cone Midbody Cleavage Furrow Synapse	Extracellular Space Cytoplasm Actin Cytoskeleton Nuclear Matrix Z Disc I Band Extracellular Exosome
	Molecular Function	Actin Binding Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Protein Binding Actin Filament Binding
	Biological Process	Cell Morphogenesis Protein Dephosphorylation Actin Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Synaptic Plasticity Regulation Of Cellular Protein Metabolic Process Peptidyl-tyrosine Dephosphorylation Cellular Response To ATP Excitatory Chemical Synaptic Transmission Positive Regulation Of Neuron Death Positive Regulation Of AMPA Glutamate Receptor Clustering Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Excitatory Postsynaptic Potential	Skeletal Muscle Tissue Development Actin Filament Depolymerization Actin Filament Fragmentation Positive Regulation Of Actin Filament Depolymerization Sarcomere Organization Muscle Cell Cellular Homeostasis Cell Motility Actin Filament Severing
Pathways
Drugs
Diseases			Nemaline myopathy
GWAS		Brain morphology (MOSTest) ( 32665545) Mean platelet volume ( 27863252) Platelet count ( 32888494)	Atrial fibrillation ( 30061737 29892015) Hip circumference adjusted for BMI ( 28552196)
Interacting Genes		6 interacting genes: ACTB AKT1 CFL1 CFL2 CORO1B DSTN	13 interacting genes: ACTB ACTG1 CAP2 CFL1 DSTN LIMK1 POT1 RAB2A RNF4 SSH1 STK11 TRIM7 UBE2I
Entrez ID		54434	1073
HPRD ID		09486	03262
Ensembl ID		ENSG00000084112	ENSG00000165410
Uniprot IDs		Q8WYL5	Q549N0 Q9Y281
PDB IDs
Enriched GO Terms of Interacting Partners?
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