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CDK8 and ERCC3
Data Source:
BioGRID
(enzymatic study)
CDK8
ERCC3
Description
cyclin dependent kinase 8
ERCC excision repair 3, TFIIH core complex helicase subunit
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Mediator Complex
Protein-containing Complex
Nucleotide-excision Repair Factor 3 Complex
Transcription Factor TFIIH Core Complex
Nucleus
Nucleoplasm
Transcription Factor TFIID Complex
Transcription Factor TFIIH Holo Complex
Transcription Preinitiation Complex
Molecular Function
Protein Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
DNA Binding
Damaged DNA Binding
Helicase Activity
Protein Binding
ATP Binding
Protein C-terminus Binding
Transcription Factor Binding
ATPase Activity
3'-5' DNA Helicase Activity
Protein N-terminus Binding
Biological Process
Transcription Initiation From RNA Polymerase II Promoter
Protein Phosphorylation
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Cycle
Nucleotide-excision Repair, DNA Duplex Unwinding
DNA Topological Change
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Stabilization
Nucleotide-excision Repair, Preincision Complex Assembly
Nucleotide-excision Repair, DNA Incision, 3'-to Lesion
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Apoptotic Process
Response To Oxidative Stress
Protein Localization
Response To UV
Viral Process
Nucleotide-excision Repair, DNA Incision
Hair Cell Differentiation
Positive Regulation Of Apoptotic Process
Embryonic Organ Development
Global Genome Nucleotide-excision Repair
Regulation Of Mitotic Cell Cycle Phase Transition
Pathways
PPARA activates gene expression
NOTCH1 Intracellular Domain Regulates Transcription
Generic Transcription Pathway
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Tat-mediated elongation of the HIV-1 transcript
NoRC negatively regulates rRNA expression
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
mRNA Capping
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Alvocidib
Diseases
Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS
Immune response to measles-mumps-rubella vaccine (
24811271
)
Sporadic pituitary adenoma (
26029870
)
Interacting Genes
38 interacting genes:
AURKA
BCL6
BMPR1A
BUB1
CCNC
CCND1
CCNH
CDH1
CDKN2B
CTDP1
ERBB2
ERCC3
ESR1
ESR2
H3C14
KRAS
MAML1
MBP
MCC
MED12
MED21
MED25
MED26
MED8
MED9
MLH3
MYC
NRIP1
POLR2A
PRMT5
SMAD2
SMAD3
SMARCA4
SREBF1
SUZ12
TOP1
TP53
WDR77
37 interacting genes:
ADAMTSL4
AR
BCR
BLZF1
CCNC
CCNH
CDC42
CDK7
CDK8
CEP70
CEP76
E2F1
ERCC2
GOLGA2
GTF2E1
GTF2E2
GTF2H1
GTF2H2
GTF2H3
GTF2H4
GTF2H5
KPNA3
MAGED1
MCF2
MNAT1
MSANTD2
PSMC5
RAD52
ROPN1
SNW1
SRPK2
TP53
TRIM14
TRIM27
XIAP
XPC
ZSCAN1
Entrez ID
1024
2071
HPRD ID
04422
00593
Ensembl ID
ENSG00000132964
ENSG00000163161
Uniprot IDs
P49336
B3KRG2
B3KTH1
G3V1S1
P19447
PDB IDs
3RGF
4CRL
4F6S
4F6U
4F6W
4F70
4F7J
4F7L
4F7N
4F7S
4G6L
5BNJ
5CEI
5FGK
5HBE
5HBH
5HBJ
5HNB
5HVY
5I5Z
5ICP
5IDN
5IDP
5XQX
5XS2
6QTG
6QTJ
6R3S
6T41
4ERN
5IVW
5IY6
5IY7
5IY8
5IY9
5OF4
6NMI
6O9L
6O9M
6RO4
Enriched GO Terms of Interacting Partners
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