NBPF19 and IL10

Data Source:
BioGRID (two hybrid)

		NBPF19	IL10
Description		NBPF member 19	interleukin 10
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Extracellular Region Extracellular Space
	Molecular Function		Cytokine Activity Interleukin-10 Receptor Binding Protein Binding Growth Factor Activity Protein Dimerization Activity
	Biological Process		Negative Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Positive Regulation Of Endothelial Cell Proliferation Response To Molecule Of Bacterial Origin Positive Regulation Of Immunoglobulin Production Negative Regulation Of Cytokine Production Involved In Immune Response Negative Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of B Cell Apoptotic Process Cytoplasmic Sequestering Of NF-kappaB Aging Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Negative Regulation Of Autophagy Response To Activity Response To Inactivity Cytokine-mediated Signaling Pathway Hemopoiesis B Cell Differentiation Leukocyte Chemotaxis Negative Regulation Of Myeloid Dendritic Cell Activation Negative Regulation Of B Cell Proliferation Negative Regulation Of Interferon-alpha Production Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-1 Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-18 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Response To Insulin Negative Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Heterotypic Cell-cell Adhesion Response To Carbon Monoxide Interleukin-12-mediated Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Type 2 Immune Response B Cell Proliferation Negative Regulation Of T Cell Proliferation Response To Drug Defense Response To Bacterium Defense Response To Protozoan Positive Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Isotype Switching Negative Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Inflammatory Response Regulation Of Synapse Organization Negative Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of DNA-binding Transcription Factor Activity Response To Glucocorticoid Negative Regulation Of Cytokine Activity Branching Involved In Labyrinthine Layer Morphogenesis Cellular Response To Lipopolysaccharide Cellular Response To Estradiol Stimulus Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Endothelial Cell Apoptotic Process Liver Regeneration Positive Regulation Of Plasma Cell Differentiation Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Regulation Of Response To Wounding Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Sensory Perception Of Pain Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Signaling Receptor Activity Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways			Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation CD163 mediating an anti-inflammatory response FCGR3A-mediated IL10 synthesis
Drugs			CRx-139 LLL-3348
Diseases			Graft-versus-host disease Allograft rejection
GWAS		Serum uric acid levels ( 30993211)	Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Behcet's disease ( 20622878 20622879) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28008999 28067908 23128233) Itch intensity from mosquito bite ( 28199695) Mosquito bite size ( 28199695) Pediatric autoimmune diseases ( 26301688) Systemic lupus erythematosus ( 26502338 28714469 19838195) Type 1 diabetes ( 21829393 25751624 19430480 30572963) Ulcerative colitis ( 19915572 28067908 26398853 20228798 20228799 18836448 21297633)
Interacting Genes		223 interacting genes: ADAM12 ADAMTSL4 AGXT ALDH16A1 ALPP ANKS1A AQP1 ATG9A ATP5F1D BCAM BMP7 BRME1 CARHSP1 CATSPER1 CCER1 CD164 CELF5 CERK CHCHD3 CHIC2 CHRD CHRNG CNNM3 COL8A1 CREB5 CRH CRY2 CST2 CST9L CTNNBIP1 CTSZ CXCL16 CYHR1 CYP21A2 CYSRT1 DAGLB DALRD3 DBH DGKQ DHRS1 DMRT3 DOCK2 DRD5 EMC7 F10 FADS2 FAM221A FAM71C FAM90A1 FBXW5 FRS3 FTHL17 FZD10 GLP1R GLYAT GNE GSTP1 HAPLN2 HBA1 HBA2 HBZ HCK HHEX HOXA1 HOXB9 HOXC8 HPCAL1 HSPA12B ICAM4 IL10 INO80B INS ITGB2 ITGB4 ITGB5 JOSD1 KCNS2 KCTD15 KLHL38 KLK8 KPRP KRT83 KRTAP10-1 KRTAP10-10 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-2 KRTAP13-3 KRTAP13-4 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP4-11 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE4A LCE5A LMNTD2 LNX1 LRFN4 LYVE1 MACO1 MAPKBP1 MELTF MFSD13A MOS MRGBP MRPL40 MTA1 MXD3 MXI1 MYO15B MYPOP NECTIN2 NECTIN3 NEDD9 NMU NPDC1 NR1D2 NTM NTN4 OLFM2 OTX1 P2RX4 P2RX7 P2RY6 PCSK5 PGAP6 PHLDA1 PIGS PLEKHN1 PRF1 PRR35 PSMA1 PTK7 PTPMT1 PVR R3HDM2 RAB3IL1 RAMP3 RASD1 RECK RNF111 RPS19BP1 RTN4RL1 SCNM1 SEMA3B SEMA4C SHFL SLC22A5 SLC23A1 SLC43A2 SLC5A5 SLC6A20 SMCP SPATA24 SPATA8 SPG7 SPPL2C SPRY1 STAC STK16 TAPBPL TCAF1 THAP7 TLE5 TMEFF2 TMEM150A TMIE TNIP3 TNS2 TRAPPC14 TRIM42 TROAP TSPAN4 TTPA UTP23 UXT VASN WDR25 ZDHHC1 ZNF124 ZNF319 ZNF330 ZNF408 ZNF414 ZNF417 ZNF440 ZNF446 ZNF497 ZNF580 ZNF581 ZNF587 ZNF648 ZNF672 ZNF786 ZNF837	10 interacting genes: A2M GLRX3 IL10RA IL10RB KRTAP1-3 KRTAP10-8 KRTAP4-1 NBPF19 NOTCH2NLA YY1
Entrez ID		101060226	3586
HPRD ID			00495
Ensembl ID		ENSG00000271383	ENSG00000136634
Uniprot IDs			P22301 Q6FGW4
PDB IDs			1ILK 1INR 1J7V 1LK3 1Y6K 2H24 2ILK
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?