NBPF19 and ITGB2

Data Source:
BioGRID (two hybrid)

		NBPF19	ITGB2
Description		NBPF member 19	integrin subunit beta 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Integrin AlphaL-beta2 Complex Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Specific Granule Membrane Receptor Complex Plasma Membrane Raft Extracellular Exosome Tertiary Granule Membrane Cytoplasmic Region Ficolin-1-rich Granule Membrane Extracellular Vesicle
	Molecular Function		Amyloid-beta Binding Complement Component C3b Binding Integrin Binding Protein Binding Protein Kinase Binding ICAM-3 Receptor Activity Heat Shock Protein Binding Cargo Receptor Activity Metal Ion Binding Cell Adhesion Molecule Binding
	Biological Process		Microglial Cell Activation Leukocyte Migration Involved In Inflammatory Response Receptor-mediated Endocytosis Phagocytosis, Engulfment Apoptotic Process Inflammatory Response Cell Adhesion Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell-cell Signaling Aging Regulation Of Cell Shape Cell Migration Cytokine-mediated Signaling Pathway Natural Killer Cell Activation Extracellular Matrix Organization Neutrophil Chemotaxis Receptor Internalization Positive Regulation Of Superoxide Anion Generation Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Toll-like Receptor 4 Signaling Pathway Endodermal Cell Differentiation Receptor Clustering Neutrophil Degranulation Positive Regulation Of Neutrophil Degranulation Endothelial Cell Migration Cellular Extravasation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Negative Regulation Of Dopamine Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Leukocyte Migration Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Low-density Lipoprotein Particle Stimulus Positive Regulation Of Protein Targeting To Membrane Amyloid-beta Clearance Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Neuron Death Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Neutrophil Migration Positive Regulation Of Prostaglandin-E Synthase Activity
Pathways			Toll Like Receptor 4 (TLR4) Cascade Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Integrin cell surface interactions Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation
Drugs
Diseases			Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
GWAS		Serum uric acid levels ( 30993211)	Heel bone mineral density ( 28869591) Lymphocyte counts ( 32888494) Monocyte count ( 32888494)
Interacting Genes		223 interacting genes: ADAM12 ADAMTSL4 AGXT ALDH16A1 ALPP ANKS1A AQP1 ATG9A ATP5F1D BCAM BMP7 BRME1 CARHSP1 CATSPER1 CCER1 CD164 CELF5 CERK CHCHD3 CHIC2 CHRD CHRNG CNNM3 COL8A1 CREB5 CRH CRY2 CST2 CST9L CTNNBIP1 CTSZ CXCL16 CYHR1 CYP21A2 CYSRT1 DAGLB DALRD3 DBH DGKQ DHRS1 DMRT3 DOCK2 DRD5 EMC7 F10 FADS2 FAM221A FAM71C FAM90A1 FBXW5 FRS3 FTHL17 FZD10 GLP1R GLYAT GNE GSTP1 HAPLN2 HBA1 HBA2 HBZ HCK HHEX HOXA1 HOXB9 HOXC8 HPCAL1 HSPA12B ICAM4 IL10 INO80B INS ITGB2 ITGB4 ITGB5 JOSD1 KCNS2 KCTD15 KLHL38 KLK8 KPRP KRT83 KRTAP10-1 KRTAP10-10 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-2 KRTAP13-3 KRTAP13-4 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP4-11 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE4A LCE5A LMNTD2 LNX1 LRFN4 LYVE1 MACO1 MAPKBP1 MELTF MFSD13A MOS MRGBP MRPL40 MTA1 MXD3 MXI1 MYO15B MYPOP NECTIN2 NECTIN3 NEDD9 NMU NPDC1 NR1D2 NTM NTN4 OLFM2 OTX1 P2RX4 P2RX7 P2RY6 PCSK5 PGAP6 PHLDA1 PIGS PLEKHN1 PRF1 PRR35 PSMA1 PTK7 PTPMT1 PVR R3HDM2 RAB3IL1 RAMP3 RASD1 RECK RNF111 RPS19BP1 RTN4RL1 SCNM1 SEMA3B SEMA4C SHFL SLC22A5 SLC23A1 SLC43A2 SLC5A5 SLC6A20 SMCP SPATA24 SPATA8 SPG7 SPPL2C SPRY1 STAC STK16 TAPBPL TCAF1 THAP7 TLE5 TMEFF2 TMEM150A TMIE TNIP3 TNS2 TRAPPC14 TRIM42 TROAP TSPAN4 TTPA UTP23 UXT VASN WDR25 ZDHHC1 ZNF124 ZNF319 ZNF330 ZNF408 ZNF414 ZNF417 ZNF440 ZNF446 ZNF497 ZNF580 ZNF581 ZNF587 ZNF648 ZNF672 ZNF786 ZNF837	56 interacting genes: ADAMTSL4 APOL2 C3 CD14 CD226 CD82 COPS3 COPS5 CYSRT1 CYTH1 CYTH2 DAB1 DOK1 EGFR ESM1 FCER2 FHL2 FUT4 HP ICAM1 ICAM2 ICAM3 ICAM4 ICAM5 ILK ITGAD ITGAM ITGAX KNG1 KRT31 KRTAP10-8 LHFPL5 MS4A7 MTIF3 NBPF19 NOTCH2NLA NUMB PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRTN3 PTK2 PTK2B RACK1 RANBP9 RDX SCML1 SHARPIN SYK TLN1 TM4SF18 UPK1B VNN2
Entrez ID		101060226	3689
HPRD ID			02506
Ensembl ID		ENSG00000271383	ENSG00000160255
Uniprot IDs			A0A494C0X7 B4E0R1 P05107
PDB IDs			1JX3 1L3Y 1YUK 2JF1 2P26 2P28 2V7D 3K6S 3K71 3K72 4NEH 4NEN 5E6R 5E6S 5E6U 5E6V 5E6W 5E6X 5ES4 5XR1 5ZAZ
Enriched GO Terms of Interacting Partners?
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