OSBPL2 and VAPB

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)

		OSBPL2	VAPB
Description		oxysterol binding protein like 2	VAMP associated protein B and C
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GO Annotations	Cellular Component	Lipid Droplet Cytosol Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Intracellular Membrane-bounded Organelle	Golgi Membrane Cell Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Membrane Endoplasmic Reticulum Exit Site
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Phosphatidylinositol Transporter Activity Sterol Transporter Activity Cholesterol Binding Sterol Binding Intermembrane Cholesterol Transfer Activity	Protein Binding Microtubule Binding Enzyme Binding FFAT Motif Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Beta-tubulin Binding
	Biological Process	Bile Acid Biosynthetic Process Plasma Membrane Organization Phospholipid Transport Cholesterol Transport Intracellular Cholesterol Transport Protein Homotetramerization	Cellular Calcium Ion Homeostasis ER To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Modulation By Virus Of Host Morphology Or Physiology Sphingolipid Biosynthetic Process Endoplasmic Reticulum Unfolded Protein Response IRE1-mediated Unfolded Protein Response Positive Regulation Of Viral Genome Replication Endoplasmic Reticulum-plasma Membrane Tethering COPII-coated Vesicle Budding Endoplasmic Reticulum Membrane Organization
Pathways		Synthesis of bile acids and bile salts	Sphingolipid de novo biosynthesis
Drugs
Diseases			Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD) Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Estimated glomerular filtration rate ( 31152163) Femoral neck bone mineral density ( 29499414) Lumbar spine bone mineral density ( 29499414) Prostate cancer ( 23535732)
Interacting Genes		1 interacting genes: VAPB	16 interacting genes: AQP2 EMD GLP1R GPR25 KCNB1 MTNR1A OSBPL2 STX1A STX2 STX4 STX5 USP20 VAMP1 VAMP2 VHL VKORC1
Entrez ID		9885	9217
HPRD ID		09473	09300
Ensembl ID		ENSG00000130703	ENSG00000124164
Uniprot IDs		B4DKJ8 E7ET92 Q9H1P3	O95292 Q53XM7
PDB IDs		5ZM8	2MDK 3IKK
Enriched GO Terms of Interacting Partners?
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