VAPB and OSBPL2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)

		VAPB	OSBPL2
Description		VAMP associated protein B and C	oxysterol binding protein like 2
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GO Annotations	Cellular Component	Golgi Membrane Cell Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Membrane Endoplasmic Reticulum Exit Site	Lipid Droplet Cytosol Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Microtubule Binding Enzyme Binding FFAT Motif Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Beta-tubulin Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Phosphatidylinositol Transporter Activity Sterol Transporter Activity Cholesterol Binding Sterol Binding Intermembrane Cholesterol Transfer Activity
	Biological Process	Cellular Calcium Ion Homeostasis ER To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Modulation By Virus Of Host Morphology Or Physiology Sphingolipid Biosynthetic Process Endoplasmic Reticulum Unfolded Protein Response IRE1-mediated Unfolded Protein Response Positive Regulation Of Viral Genome Replication Endoplasmic Reticulum-plasma Membrane Tethering COPII-coated Vesicle Budding Endoplasmic Reticulum Membrane Organization	Bile Acid Biosynthetic Process Plasma Membrane Organization Phospholipid Transport Cholesterol Transport Intracellular Cholesterol Transport Protein Homotetramerization
Pathways		Sphingolipid de novo biosynthesis	Synthesis of bile acids and bile salts
Drugs
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD) Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS			Estimated glomerular filtration rate ( 31152163) Femoral neck bone mineral density ( 29499414) Lumbar spine bone mineral density ( 29499414) Prostate cancer ( 23535732)
Interacting Genes		16 interacting genes: AQP2 EMD GLP1R GPR25 KCNB1 MTNR1A OSBPL2 STX1A STX2 STX4 STX5 USP20 VAMP1 VAMP2 VHL VKORC1	1 interacting genes: VAPB
Entrez ID		9217	9885
HPRD ID		09300	09473
Ensembl ID		ENSG00000124164	ENSG00000130703
Uniprot IDs		O95292 Q53XM7	B4DKJ8 E7ET92 Q9H1P3
PDB IDs		2MDK 3IKK	5ZM8
Enriched GO Terms of Interacting Partners?
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