MDC1 and ZNF251

Number of citations of the paper that reports this interaction (PubMedID 22990118)
46

Data Source:
BioGRID (two hybrid)

		MDC1	ZNF251
Description		mediator of DNA damage checkpoint 1	zinc finger protein 251
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Focal Adhesion Nuclear Body	Nucleus
	Molecular Function	Protein Binding Protein C-terminus Binding Identical Protein Binding FHA Domain Binding	DNA Binding Metal Ion Binding
	Biological Process	Double-strand Break Repair Via Nonhomologous End Joining Intra-S DNA Damage Checkpoint	Regulation Of Transcription, DNA-templated
Pathways		SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends TP53 Regulates Transcription of DNA Repair Genes G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Eosinophil counts ( 31272903)	Logical memory (immediate recall) in normal cognition ( 29274321)
Interacting Genes		39 interacting genes: ANAPC1 ATM BARD1 BRCA1 CASP3 CENPC CHEK2 COPS5 CREBBP CSNK2A1 DTX2 EP300 GATA4 H2AX HDAC10 HDAC8 HINFP NBN NCL NSD2 PIAS1 PIAS4 PRIM1 RAD50 RAD51 RNF8 SMC1A SRPK2 SUMO2 TNKS2 TP53 TP53BP1 UIMC1 USP13 USP15 USP28 VAMP5 WRN ZNF251	8 interacting genes: FEZ1 FEZ2 MDC1 MX1 PAXIP1 SMAD1 SPTBN1 TSC22D2
Entrez ID		9656	90987
HPRD ID		16252	19696
Ensembl ID		ENSG00000137337	ENSG00000198169
Uniprot IDs		A0A1U9XBC1 A1Z5I9 Q14676	Q9BRH9
PDB IDs		2ADO 2AZM 2ETX 3K05 3UEO 3UMZ 3UN0 3UNM 3UNN 3UOT
Enriched GO Terms of Interacting Partners?
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