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MDC1

Description mediator of DNA damage checkpoint 1
Image
GO Annotations Cellular Component
  • Nucleus
  • Nucleoplasm
  • Chromosome
  • Focal Adhesion
  • Nuclear Body
Molecular Function
  • Protein Binding
  • Protein C-terminus Binding
  • Identical Protein Binding
  • FHA Domain Binding
Biological Process
  • Double-strand Break Repair Via Nonhomologous End Joining
  • Intra-S DNA Damage Checkpoint
Pathways
  • SUMOylation of DNA damage response and repair proteins
  • Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
  • Nonhomologous End-Joining (NHEJ)
  • Processing of DNA double-strand break ends
  • TP53 Regulates Transcription of DNA Repair Genes
  • G2/M DNA damage checkpoint
Drugs
Diseases
GWAS
  • Autism spectrum disorder or schizophrenia ( 28540026)
  • Blood protein levels ( 28240269)
  • Eosinophil counts ( 31272903)
Interacting Genes 39 interacting genes: ANAPC1 ATM BARD1 BRCA1 CASP3 CENPC CHEK2 COPS5 CREBBP CSNK2A1 DTX2 EP300 GATA4 H2AX HDAC10 HDAC8 HINFP NBN NCL NSD2 PIAS1 PIAS4 PRIM1 RAD50 RAD51 RNF8 SMC1A SRPK2 SUMO2 TNKS2 TP53 TP53BP1 UIMC1 USP13 USP15 USP28 VAMP5 WRN ZNF251
Entrez ID 9656
HPRD ID 16252
Ensembl ID ENSG00000137337
Uniprot IDs A0A1U9XBC1 A1Z5I9 Q14676
PDB IDs 2ADO 2AZM 2ETX 3K05 3UEO 3UMZ 3UN0 3UNM 3UNN 3UOT
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025

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