MDC1 and RNF8

Number of citations of the paper that reports this interaction (PubMedID 18001825)
475

Data Source:
HPRD (in vitro)

		MDC1	RNF8
Description		mediator of DNA damage checkpoint 1	ring finger protein 8
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Focal Adhesion Nuclear Body	Ubiquitin Ligase Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Midbody Site Of Double-strand Break
	Molecular Function	Protein Binding Protein C-terminus Binding Identical Protein Binding FHA Domain Binding	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Histone Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding Ubiquitin Protein Ligase Activity
	Biological Process	Double-strand Break Repair Via Nonhomologous End Joining Intra-S DNA Damage Checkpoint	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Cell Cycle Spermatid Development Response To Ionizing Radiation Viral Process Protein Ubiquitination Histone H2A Ubiquitination Histone H2B Ubiquitination Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Spermatogenesis, Exchange Of Chromosomal Proteins Interstrand Cross-link Repair Histone Exchange Isotype Switching Positive Regulation Of DNA Repair Cell Division Protein Autoubiquitination Protein K63-linked Ubiquitination Histone H2A K63-linked Ubiquitination Protein K48-linked Ubiquitination
Pathways		SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends TP53 Regulates Transcription of DNA Repair Genes G2/M DNA damage checkpoint	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Eosinophil counts ( 31272903)	Acne (severe) ( 24927181) Restless legs syndrome ( 29029846)
Interacting Genes		39 interacting genes: ANAPC1 ATM BARD1 BRCA1 CASP3 CENPC CHEK2 COPS5 CREBBP CSNK2A1 DTX2 EP300 GATA4 H2AX HDAC10 HDAC8 HINFP NBN NCL NSD2 PIAS1 PIAS4 PRIM1 RAD50 RAD51 RNF8 SMC1A SRPK2 SUMO2 TNKS2 TP53 TP53BP1 UIMC1 USP13 USP15 USP28 VAMP5 WRN ZNF251	41 interacting genes: BLM CCDC85B CEP44 CHD4 CHEK2 EXOSC2 H2AC20 H2AX H2BC21 H2BC3 H3-3B HOMEZ JMJD1C KDM4A MAD1L1 MAGED1 MDC1 MDM2 PCNA PNMA2 POLD4 RBFOX2 RXRA RYBP SEPTIN3 SUMO2 SUMO3 TMEM79 TRIM29 UBC UBE2D1 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2V2 UBE2W VCP WASL YEATS4
Entrez ID		9656	9025
HPRD ID		16252	11521
Ensembl ID		ENSG00000137337	ENSG00000112130
Uniprot IDs		A0A1U9XBC1 A1Z5I9 Q14676	O76064
PDB IDs		2ADO 2AZM 2ETX 3K05 3UEO 3UMZ 3UN0 3UNM 3UNN 3UOT	2CSW 2PIE 4AYC 4ORH 4WHV
Enriched GO Terms of Interacting Partners?
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