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IKBKE and TICAM1
Number of citations of the paper that reports this interaction (PubMedID
12692549
)
774
Data Source:
HPRD
(in vivo)
IKBKE
TICAM1
Description
inhibitor of nuclear factor kappa B kinase subunit epsilon
toll like receptor adaptor molecule 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Endosome Membrane
PML Body
Mitochondrial Membrane
Mitochondrion
Autophagosome
Cytosol
Endosome Membrane
Ripoptosome
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
NF-kappaB-inducing Kinase Activity
Protein Binding
ATP Binding
IkappaB Kinase Activity
Protein Phosphatase Binding
Ubiquitin Protein Ligase Binding
K48-linked Polyubiquitin Modification-dependent Protein Binding
Identical Protein Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
Protein Binding
Protein Kinase Binding
Biological Process
Protein Phosphorylation
Immune Response
I-kappaB Phosphorylation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Lipid Storage
Viral Process
Peptidyl-serine Phosphorylation
Negative Regulation Of Type I Interferon Production
Response To Type I Interferon
Response To Interferon-beta
TRIF-dependent Toll-like Receptor Signaling Pathway
NIK/NF-kappaB Signaling
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Cellular Response To Virus
Macrophage Activation Involved In Immune Response
Positive Regulation Of Myeloid Dendritic Cell Cytokine Production
MyD88-independent Toll-like Receptor Signaling Pathway
Inflammatory Response
I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Autophagy
Positive Regulation Of Gene Expression
Viral Process
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Protein Ubiquitination
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Protein Binding
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Natural Killer Cell Activation
Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Protein Complex Assembly
Response To Exogenous DsRNA
Positive Regulation Of Chemokine Biosynthetic Process
Innate Immune Response
Positive Regulation Of Interferon-beta Biosynthetic Process
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Defense Response To Virus
Necroptotic Process
Cellular Response To Lipopolysaccharide
Apoptotic Signaling Pathway
Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways
SUMOylation of immune response proteins
TICAM1-dependent activation of IRF3/IRF7
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Caspase activation via Death Receptors in the presence of ligand
MyD88-independent TLR4 cascade
Toll Like Receptor 3 (TLR3) Cascade
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
TRIF-mediated programmed cell death
TICAM1 deficiency - HSE
TRAF3 deficiency - HSE
TLR3-mediated TICAM1-dependent programmed cell death
TICAM1-dependent activation of IRF3/IRF7
TICAM1,TRAF6-dependent induction of TAK1 complex
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IKK complex recruitment mediated by RIP1
TRAF6-mediated induction of TAK1 complex within TLR4 complex
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS
Lymphocyte counts (
27863252
)
Metabolite levels (
23823483
)
Psoriasis (
28537254
)
Systemic lupus erythematosus (
27399966
)
Medication use (thyroid preparations) (
31015401
)
Vitiligo (
27723757
22561518
)
Interacting Genes
22 interacting genes:
AZI2
BIRC2
BIRC3
CDC37
CHUK
CYLD
DDX3X
FKBP5
HSP90AA1
HSP90AB1
IRF3
IRF5
KTN1
MBP
NFKBIA
RELA
RIPK1
SIKE1
TANK
TICAM1
TRIM27
XIAP
24 interacting genes:
AZI2
IKBKE
IRF3
IRF7
MAVS
PIAS4
PIK3CA
RIPK1
RIPK3
SRSF4
TBK1
TICAM2
TIRAP
TLR2
TLR3
TNFAIP3
TRAF1
TRAF2
TRAF3
TRAF4
TRAF6
TRAM1
TRIM8
UBQLN1
Entrez ID
9641
148022
HPRD ID
05442
06350
Ensembl ID
ENSG00000263528
ENSG00000127666
Uniprot IDs
A0A075B7B4
Q14164
Q8IUC6
PDB IDs
2M1X
2M63
3RC4
4BSX
4C0M
5JEL
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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