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TICAM1 and RIPK3
Number of citations of the paper that reports this interaction (PubMedID
15064760
)
238
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro, in vivo)
TICAM1
RIPK3
Description
toll like receptor adaptor molecule 1
receptor interacting serine/threonine kinase 3
Image
GO Annotations
Cellular Component
Mitochondrion
Autophagosome
Cytosol
Endosome Membrane
Ripoptosome
Mitochondrion
Cytosol
Plasma Membrane
Protein-containing Complex
Molecular Function
Protein Binding
Protein Kinase Binding
Transcription Coactivator Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
NF-kappaB-inducing Kinase Activity
Protein Binding
ATP Binding
Identical Protein Binding
Protein-containing Complex Binding
Biological Process
Macrophage Activation Involved In Immune Response
Positive Regulation Of Myeloid Dendritic Cell Cytokine Production
MyD88-independent Toll-like Receptor Signaling Pathway
Inflammatory Response
I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Autophagy
Positive Regulation Of Gene Expression
Viral Process
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Protein Ubiquitination
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Protein Binding
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Natural Killer Cell Activation
Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Protein Complex Assembly
Response To Exogenous DsRNA
Positive Regulation Of Chemokine Biosynthetic Process
Innate Immune Response
Positive Regulation Of Interferon-beta Biosynthetic Process
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Defense Response To Virus
Necroptotic Process
Cellular Response To Lipopolysaccharide
Apoptotic Signaling Pathway
Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Regulation Of T Cell Mediated Cytotoxicity
Regulation Of Adaptive Immune Response
Cellular Protein Modification Process
Signal Transduction
I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Phosphatase Activity
Activation Of Protein Kinase Activity
Regulation Of Interferon-gamma Production
T Cell Differentiation In Thymus
NIK/NF-kappaB Signaling
T Cell Homeostasis
Regulation Of Activated T Cell Proliferation
Protein Autophosphorylation
Lymph Node Development
Spleen Development
Thymus Development
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Ligase Activity
Positive Regulation Of Oxidoreductase Activity
Positive Regulation Of Necroptotic Process
Regulation Of Activation-induced Cell Death Of T Cells
Necroptotic Process
Cellular Response To Hydrogen Peroxide
Apoptotic Signaling Pathway
Programmed Necrotic Cell Death
Positive Regulation Of Nucleic Acid-templated Transcription
Amyloid Fibril Formation
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Caspase activation via Death Receptors in the presence of ligand
MyD88-independent TLR4 cascade
Toll Like Receptor 3 (TLR3) Cascade
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
TRIF-mediated programmed cell death
TICAM1 deficiency - HSE
TRAF3 deficiency - HSE
TLR3-mediated TICAM1-dependent programmed cell death
TICAM1-dependent activation of IRF3/IRF7
TICAM1,TRAF6-dependent induction of TAK1 complex
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IKK complex recruitment mediated by RIP1
TRAF6-mediated induction of TAK1 complex within TLR4 complex
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
TRIF-mediated programmed cell death
TRP channels
RIPK1-mediated regulated necrosis
TLR3-mediated TICAM1-dependent programmed cell death
IKK complex recruitment mediated by RIP1
Drugs
Diseases
GWAS
Medication use (thyroid preparations) (
31015401
)
Vitiligo (
27723757
22561518
)
Diastolic blood pressure (
27841878
)
Heel bone mineral density (
30598549
)
Interacting Genes
24 interacting genes:
AZI2
IKBKE
IRF3
IRF7
MAVS
PIAS4
PIK3CA
RIPK1
RIPK3
SRSF4
TBK1
TICAM2
TIRAP
TLR2
TLR3
TNFAIP3
TRAF1
TRAF2
TRAF3
TRAF4
TRAF6
TRAM1
TRIM8
UBQLN1
22 interacting genes:
BIRC2
BIRC3
BUB1B
DAXX
GBE1
H1-5
HELQ
HSPBAP1
IL24
NME8
PELI1
RFX6
RIPK1
SRPK2
TICAM1
TLE6
TMEM44
TNFRSF1A
TRAF2
UTP11
XIAP
ZSCAN20
Entrez ID
148022
11035
HPRD ID
06350
09315
Ensembl ID
ENSG00000127666
ENSG00000129465
Uniprot IDs
Q8IUC6
Q9Y572
PDB IDs
2M1X
2M63
3RC4
4BSX
4C0M
5JEL
5V7Z
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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