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TICAM1 and TRAF1
Number of citations of the paper that reports this interaction (PubMedID
16323247
)
19
Data Source:
HPRD
(in vivo, two hybrid)
TICAM1
TRAF1
Description
toll like receptor adaptor molecule 1
TNF receptor associated factor 1
Image
GO Annotations
Cellular Component
Mitochondrion
Autophagosome
Cytosol
Endosome Membrane
Ripoptosome
Cytoplasm
Cytosol
Cytoplasmic Side Of Plasma Membrane
Plasma Membrane Receptor Complex
Molecular Function
Protein Binding
Protein Kinase Binding
Tumor Necrosis Factor Receptor Binding
Protein Binding
Zinc Ion Binding
Ubiquitin Protein Ligase Binding
Thioesterase Binding
Identical Protein Binding
Biological Process
Macrophage Activation Involved In Immune Response
Positive Regulation Of Myeloid Dendritic Cell Cytokine Production
MyD88-independent Toll-like Receptor Signaling Pathway
Inflammatory Response
I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Autophagy
Positive Regulation Of Gene Expression
Viral Process
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Protein Ubiquitination
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Protein Binding
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Natural Killer Cell Activation
Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Protein Complex Assembly
Response To Exogenous DsRNA
Positive Regulation Of Chemokine Biosynthetic Process
Innate Immune Response
Positive Regulation Of Interferon-beta Biosynthetic Process
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Defense Response To Virus
Necroptotic Process
Cellular Response To Lipopolysaccharide
Apoptotic Signaling Pathway
Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Apoptotic Process
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of JNK Cascade
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein-containing Complex Assembly
Protein K63-linked Ubiquitination
Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Caspase activation via Death Receptors in the presence of ligand
MyD88-independent TLR4 cascade
Toll Like Receptor 3 (TLR3) Cascade
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
TRIF-mediated programmed cell death
TICAM1 deficiency - HSE
TRAF3 deficiency - HSE
TLR3-mediated TICAM1-dependent programmed cell death
TICAM1-dependent activation of IRF3/IRF7
TICAM1,TRAF6-dependent induction of TAK1 complex
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IKK complex recruitment mediated by RIP1
TRAF6-mediated induction of TAK1 complex within TLR4 complex
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Drugs
Diseases
GWAS
Medication use (thyroid preparations) (
31015401
)
Vitiligo (
27723757
22561518
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Celiac disease or Rheumatoid arthritis (
21383967
)
Lymphocyte counts (
27863252
)
Pulse pressure (
30578418
)
Rheumatoid arthritis (
30891314
24782177
23143596
24390342
20453842
19503088
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
Interacting Genes
24 interacting genes:
AZI2
IKBKE
IRF3
IRF7
MAVS
PIAS4
PIK3CA
RIPK1
RIPK3
SRSF4
TBK1
TICAM2
TIRAP
TLR2
TLR3
TNFAIP3
TRAF1
TRAF2
TRAF3
TRAF4
TRAF6
TRAM1
TRIM8
UBQLN1
186 interacting genes:
A1CF
ABHD17A
ACTN3
AKAP17A
AQP1
ARNT2
ARSJ
BARD1
BCAS2
BCL6
BEX2
BEX3
BIRC2
BIRC3
C1orf109
C1orf216
C2CD6
CARHSP1
CASP10
CASP3
CASP6
CASP8
CCDC116
CCDC120
CCDC146
CCDC198
CCHCR1
CD40
CDCA3
CDKN1A
CDKN2B
CFLAR
CHCHD3
CNTRL
COX5B
CRYGA
CYB5R2
DEPTOR
DGCR6
DMRT3
DOK3
EDAR
EHHADH
EWSR1
FAM161A
FAM86C1P
FBF1
FBXL18
FOSL2
GATA1
GATA2
GATAD2B
GEM
GFI1B
GIT2
GLRX3
GMCL2
GNG5
GOLGA2
GORASP2
GRAP2
HAUS1
HEY2
HIVEP3
HMG20B
HOXA1
HOXD12
IKBKB
JOSD1
KIAA1217
KIF1A
KLHL38
KPNA2
LATS1
LCOR
LNX1
LNX2
LTBR
MACIR
MAP3K14
MAP6
MAPRE2
METTL17
MORN3
MOS
MYEF2
NEBL
NOL4L-DT
NTAQ1
NUFIP2
NUP58
OLIG3
PBX3
PDE4D
PHF21A
PIN1
PKN1
PLAC8
PLEKHN1
POM121L4P
POP5
PPP1R13B
PRDM7
PRKAB2
PSMA1
PSMB1
QRICH1
RASAL2
RASSF5
RBCK1
RBM41
RBM45
RIPK1
RIPK2
RNF31
RTP5
SCNM1
SDCBP2
SH3GLB2
SHARPIN
SHFL
SIK3
SLC25A48
SLC25A6
SNW1
SPG21
SPOP
SRC
SSC5D
STK3
SUMO2
SYCE1
TANK
TBC1D16
TCL1A
TEAD4
TFAP4
TFPT
THAP7
TICAM1
TIFA
TLE5
TNFAIP3
TNFRSF11A
TNFRSF12A
TNFRSF14
TNFRSF17
TNFRSF18
TNFRSF19
TNFRSF1A
TNFRSF1B
TNFRSF4
TNFRSF8
TNFRSF9
TNFSF9
TRADD
TRAF2
TRAF3IP2
TRAF6
TRAIP
TRIM23
TRIM37
TRIM42
TRPV6
TSSC4
USP7
WAC
ZBTB1
ZBTB16
ZC2HC1C
ZFYVE21
ZFYVE26
ZNF124
ZNF20
ZNF250
ZNF417
ZNF440
ZNF502
ZNF512B
ZNF564
ZNF572
ZNF581
ZNF587
ZNF662
ZNF688
ZNF697
Entrez ID
148022
7185
HPRD ID
06350
03418
Ensembl ID
ENSG00000127666
ENSG00000056558
Uniprot IDs
Q8IUC6
Q13077
PDB IDs
2M1X
2M63
3RC4
4BSX
4C0M
5JEL
3M0D
5E1T
5H10
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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