CD53 and CD2

Number of citations of the paper that reports this interaction (PubMedID 1346273)
13

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		CD53	CD2
Description		CD53 molecule	CD2 molecule
Image		No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Surface Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Protein-containing Complex Membrane Raft Anchored Component Of Plasma Membrane
	Molecular Function	Protein Binding	Signaling Receptor Binding Protein Binding Receptor Tyrosine Kinase Binding Signaling Receptor Activity Identical Protein Binding Protein Self-association
	Biological Process	Signal Transduction Neutrophil Degranulation Positive Regulation Of Myoblast Fusion	Membrane Raft Polarization Apoptotic Process Cell Surface Receptor Signaling Pathway Natural Killer Cell Activation Positive Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion T Cell Activation Regulation Of T Cell Differentiation Leukocyte Migration Cell-cell Adhesion Positive Regulation Of Interferon-gamma Secretion Positive Regulation Of Interleukin-8 Secretion
Pathways		Neutrophil degranulation	Cell surface interactions at the vascular wall
Drugs			Alefacept
Diseases
GWAS		Cytomegalovirus antibody response ( 21993531) Obesity-related traits ( 23251661)	Body mass index ( 28552196) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)
Interacting Genes		6 interacting genes: CD2 CD4 CD9 GGT1 IL2 IL4	21 interacting genes: CD247 CD2AP CD2BP2 CD4 CD48 CD5 CD53 CD58 CD59 DNAJC5 FYN LCK LGALS1 LINC00311 LYAR MXD1 PSTPIP1 PTPRC SH3KBP1 SP1 UBC
Entrez ID		963	914
HPRD ID		01054	01750
Ensembl ID		ENSG00000143119	ENSG00000116824
Uniprot IDs		B4DQB5 P19397	P06729 Q53F96
PDB IDs			1CDB 1GYA 1HNF 1L2Z 1QA9 2J6O 2J7I
Enriched GO Terms of Interacting Partners?
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