CD2 and CD2AP

Number of citations of the paper that reports this interaction (PubMedID 9741631)
189

Data Source:
HPRD (two hybrid, in vivo)

		CD2	CD2AP
Description		CD2 molecule	CD2 associated protein
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Protein-containing Complex Membrane Raft Anchored Component Of Plasma Membrane	Fibrillar Center Ruffle Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Actin Cytoskeleton Endocytic Vesicle Filamentous Actin Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Protein Binding Receptor Tyrosine Kinase Binding Signaling Receptor Activity Identical Protein Binding Protein Self-association	Vascular Endothelial Growth Factor Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding Beta-catenin Binding Protein C-terminus Binding SH3 Domain Binding Identical Protein Binding Protein-containing Complex Binding Cadherin Binding
	Biological Process	Membrane Raft Polarization Apoptotic Process Cell Surface Receptor Signaling Pathway Natural Killer Cell Activation Positive Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion T Cell Activation Regulation Of T Cell Differentiation Leukocyte Migration Cell-cell Adhesion Positive Regulation Of Interferon-gamma Secretion Positive Regulation Of Interleukin-8 Secretion	Substrate-dependent Cell Migration, Cell Extension Actin Filament Organization Cell Cycle Signal Transduction Vesicle Organization Negative Regulation Of Transforming Growth Factor Beta1 Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Protein Secretion Negative Regulation Of Small GTPase Mediated Signal Transduction Cell Division Protein-containing Complex Assembly Cell-cell Adhesion Positive Regulation Of Protein Localization To Nucleus Regulation Of Actin Cytoskeleton Reorganization
Pathways		Cell surface interactions at the vascular wall	Nephrin family interactions
Drugs		Alefacept
Diseases			Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Body mass index ( 28552196) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)	Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 21460841 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Family history of Alzheimer's disease ( 30617256) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Metabolite levels ( 23823483) Plasma homocysteine levels ( 26519441) Red cell distribution width ( 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		21 interacting genes: CD247 CD2AP CD2BP2 CD4 CD48 CD5 CD53 CD58 CD59 DNAJC5 FYN LCK LGALS1 LINC00311 LYAR MXD1 PSTPIP1 PTPRC SH3KBP1 SP1 UBC	33 interacting genes: ARAP3 BCAR1 CAPZA1 CBL CBLB CD2 CTTN FYN GRB2 GZMB HBP1 HCK HOXC11 KHDRBS1 MVB12A NPHS1 NPHS2 NR2C2 NR4A1 PDCD6IP PIK3R1 PKD2 PSTPIP1 PTGES3 RAB4A SH3GL2 SOS1 SOS2 SRC UBC UBE2I WTIP YES1
Entrez ID		914	23607
HPRD ID		01750	05026
Ensembl ID		ENSG00000116824	ENSG00000198087
Uniprot IDs		P06729 Q53F96	Q9Y5K6
PDB IDs		1CDB 1GYA 1HNF 1L2Z 1QA9 2J6O 2J7I	2FEI 2J6F 2J6K 2J6O 2J7I 3AA6 3LK4 3U23 4WCI 4X1V
Enriched GO Terms of Interacting Partners?
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