CELSR1 and PSAP

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CELSR1	PSAP
Description		cadherin EGF LAG seven-pass G-type receptor 1	prosaposin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Lysosome Lysosomal Membrane Late Endosome Plasma Membrane Aggresome Azurophil Granule Membrane Lysosomal Lumen Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Activity Calcium Ion Binding	G Protein-coupled Receptor Binding Protease Binding Beta-galactosidase Activity Protein Binding Phospholipid Binding Enzyme Activator Activity Lipid Binding Lipid Antigen Binding Protein Homodimerization Activity Ganglioside GM1 Binding Ganglioside GM2 Binding Ganglioside GM3 Binding Ganglioside GT1b Binding Ganglioside GP1c Binding
	Biological Process	Establishment Of Planar Polarity Neuron Migration Neural Tube Closure Hair Follicle Development Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Central Nervous System Development Locomotory Behavior Anterior/posterior Pattern Specification Regulation Of Actin Cytoskeleton Organization Wound Healing Establishment Of Planar Polarity Of Embryonic Epithelium Inner Ear Morphogenesis Apical Protein Localization Establishment Of Body Hair Planar Orientation Wnt Signaling Pathway, Planar Cell Polarity Pathway Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Lateral Sprouting Involved In Lung Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Protein Localization Involved In Establishment Of Planar Polarity Cell-cell Adhesion	NK T Cell Differentiation Platelet Degranulation Corneocyte Development Glucosylceramide Metabolic Process Galactosylceramide Catabolic Process Glycosphingolipid Metabolic Process Lipid Transport Intracellular Protein Transport Lysosomal Transport G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Sound Protein Secretion Gene Expression Regulation Of Autophagy Regulation Of Lipid Metabolic Process Antigen Processing And Presentation Cerebellar Purkinje Cell Differentiation Myelination Neutrophil Degranulation Positive Regulation Of MAPK Cascade Neuromuscular Process Controlling Balance Positive Regulation Of Hydrolase Activity Micturition Prostate Gland Growth Epithelial Cell Differentiation Involved In Prostate Gland Development Inclusion Body Assembly Cellular Response To Organic Substance Cochlea Development Walking Behavior Negative Regulation Of Hydrogen Peroxide-induced Cell Death Cornified Envelope Assembly Lysosomal Protein Catabolic Process Ganglioside GM1 Transport To Membrane
Pathways			Platelet degranulation Glycosphingolipid metabolism Peptide ligand-binding receptors G alpha (i) signalling events Neutrophil degranulation
Drugs			Di-Stearoyl-3-Sn-Phosphatidylethanolamine
Diseases			Krabbe disease; Globoid cell leukodystrophy Metachromatic leukodystrophy (MLD) Gaucher disease
GWAS		Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Heel bone mineral density ( 30598549) Iris color (L* coordinate) ( 30895295) Urate levels in obese individuals ( 25811787)	Asthma (childhood onset) ( 23829686) Blood protein levels ( 30072576) Seasonality and depression ( 30217971)
Interacting Genes		1 interacting genes: PSAP	18 interacting genes: BACE1 BRCA1 CD1B CELSR1 COPS6 CPEB2 CTSD ERBB2 GBA MAFF NLGN3 PRAG1 SMAD2 SMAD9 TOMM70 UBE3A USP4 ZBED1
Entrez ID		9620	5660
HPRD ID		05160	01460
Ensembl ID		ENSG00000075275	ENSG00000197746
Uniprot IDs		Q9NYQ6	A0A024QZQ2 P07602
PDB IDs			1M12 1N69 1SN6 2DOB 2GTG 2QYP 2R0R 2R1Q 2RB3 2Z9A 3BQP 3BQQ 4DDJ 4UEX 4V2O
Enriched GO Terms of Interacting Partners?
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