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CD28 and CD86
Number of citations of the paper that reports this interaction (PubMedID
11021528
)
21
Data Source:
HPRD
(in vivo)
CD28
CD86
Description
CD28 molecule
CD86 molecule
Image
GO Annotations
Cellular Component
Immunological Synapse
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Protein Complex Involved In Cell Adhesion
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Integral Component Of Membrane
Extracellular Exosome
Molecular Function
Protease Binding
SH3/SH2 Adaptor Activity
Protein Binding
Coreceptor Activity
Protein Kinase Binding
Identical Protein Binding
Virus Receptor Activity
Protein Binding
Coreceptor Activity
Signaling Receptor Activity
Biological Process
Immune System Process
Positive Regulation Of Inflammatory Response To Antigenic Stimulus
Humoral Immune Response
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
T Cell Costimulation
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-4 Production
Cytokine Biosynthetic Process
Positive Regulation Of T Cell Proliferation
T Cell Activation
Negative Regulation Of Apoptotic Process
Negative Thymic T Cell Selection
Regulatory T Cell Differentiation
Positive Regulation Of Viral Genome Replication
Positive Regulation Of Interleukin-2 Biosynthetic Process
Regulation Of Regulatory T Cell Differentiation
Positive Regulation Of Translation
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Alpha-beta T Cell Proliferation
Positive Regulation Of Isotype Switching To IgG Isotypes
Regulation Of Defense Response To Virus By Virus
T Cell Receptor Signaling Pathway
Positive Regulation Of Protein Kinase B Signaling
Apoptotic Signaling Pathway
Adaptive Immune Response
Immune Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Proliferation
Cytokine-mediated Signaling Pathway
T Cell Costimulation
Positive Regulation Of T Cell Proliferation
Negative Regulation Of T Cell Proliferation
Positive Regulation Of Lymphotoxin A Biosynthetic Process
Positive Regulation Of Interleukin-2 Biosynthetic Process
Positive Regulation Of Interleukin-4 Biosynthetic Process
Positive Regulation Of T-helper 2 Cell Differentiation
Positive Regulation Of Transcription, DNA-templated
Viral Entry Into Host Cell
Positive Regulation Of Protein Kinase B Signaling
Cellular Response To Lipopolysaccharide
Pathways
PIP3 activates AKT signaling
Nef mediated downregulation of CD28 cell surface expression
Constitutive Signaling by Aberrant PI3K in Cancer
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signaling
Interleukin-10 signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Antithymocyte immunoglobulin (rabbit)
Abatacept
Belatacept
Diseases
GWAS
Alopecia areata (
25608926
)
Celiac disease (
22057235
20190752
25920553
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Graves' disease (
21841780
)
Heschl's gyrus morphology (
25130324
)
Inflammatory bowel disease (
26192919
)
Multiple sclerosis (
31604244
24076602
)
Primary biliary cholangitis (
28425483
)
Primary sclerosing cholangitis (
23603763
27992413
)
Rheumatoid arthritis (
30423114
23143596
24390342
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
Subcutaneous adipose tissue (
29178545
)
Systemic lupus erythematosus (
28714469
)
Ulcerative colitis (
26192919
)
Diffuse large B cell lymphoma (
25261932
)
Follicular lymphoma (
25279986
)
Gut microbiota (functional units) (
27694959
)
Multiple sclerosis (
31604244
22190364
24076602
21833088
27386562
)
Selective IgA deficiency (
27723758
)
Systemic lupus erythematosus (
19838195
)
Type 2 diabetes (
30718926
)
Interacting Genes
18 interacting genes:
BCS1L
CD247
CD4
CD80
CD86
DUSP14
GRAP2
GRB2
IL12A
ITK
LCK
LRRC23
NSF
PIK3CG
PIK3R1
PIK3R2
PLCG1
PTPRC
6 interacting genes:
CD28
CD80
CTLA4
ECE2
MARCHF8
PARP1
Entrez ID
940
942
HPRD ID
01727
03011
Ensembl ID
ENSG00000178562
ENSG00000114013
Uniprot IDs
B4E0L1
P10747
A0A0X9R4E0
A8K632
P42081
PDB IDs
1YJD
3WA4
5AUL
5GJH
5GJI
6O8D
1I85
1NCN
5YXK
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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