CD86

Description		CD86 molecule
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Virus Receptor Activity Protein Binding Coreceptor Activity Signaling Receptor Activity
	Biological Process	Adaptive Immune Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway T Cell Costimulation Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Lymphotoxin A Biosynthetic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Interleukin-4 Biosynthetic Process Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Positive Regulation Of Protein Kinase B Signaling Cellular Response To Lipopolysaccharide
Pathways		PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer CD28 co-stimulation CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway CTLA4 inhibitory signaling Interleukin-10 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs		Antithymocyte immunoglobulin (rabbit) Abatacept Belatacept
Diseases
GWAS		Diffuse large B cell lymphoma ( 25261932) Follicular lymphoma ( 25279986) Gut microbiota (functional units) ( 27694959) Multiple sclerosis ( 31604244 22190364 24076602 21833088 27386562) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 19838195) Type 2 diabetes ( 30718926)
Interacting Genes		6 interacting genes: CD28 CD80 CTLA4 ECE2 MARCHF8 PARP1
Entrez ID		942
HPRD ID		03011
Ensembl ID		ENSG00000114013
Uniprot IDs		A0A0X9R4E0 A8K632 P42081
PDB IDs		1I85 1NCN 5YXK
Enriched GO Terms of Interacting Partners?
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