TAOK2 and MAP2K3

Number of citations of the paper that reports this interaction (PubMedID 9786855)
39

Data Source:
HPRD (in vivo, in vitro)

		TAOK2	MAP2K3
Description		TAO kinase 2	mitogen-activated protein kinase kinase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Cytosol Actin Cytoskeleton Integral Component Of Membrane Axon Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Neuron Projection Receptor Complex Dendritic Growth Cone Axonal Growth Cone	Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity ATP Binding Mitogen-activated Protein Kinase Kinase Binding Neuropilin Binding Tau Protein Binding Tau-protein Kinase Activity	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding
	Biological Process	Activation Of MAPKK Activity Activation Of MAPK Activity Regulation Of Cell Growth Protein Targeting To Membrane Apoptotic Process Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Regulation Of Mitotic Cell Cycle Axonogenesis Regulation Of Cell Shape Cell Migration Signal Transduction By Protein Phosphorylation Actin Cytoskeleton Organization Stress-activated Protein Kinase Signaling Cascade G2 DNA Damage Checkpoint Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase Activity Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Actin Cytoskeleton Organization Positive Regulation Of JNK Cascade Protein Autophosphorylation Focal Adhesion Assembly Stress-activated MAPK Cascade Basal Dendrite Morphogenesis Basal Dendrite Arborization	Activation Of MAPK Activity Inflammatory Response Signal Transduction Regulation Of Mitotic Cell Cycle Peptidyl-tyrosine Phosphorylation Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Cellular Response To Vascular Endothelial Growth Factor Stimulus P38MAPK Cascade Regulation Of Cytokine Biosynthetic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Cardiac Muscle Contraction
Pathways			Oxidative Stress Induced Senescence activated TAK1 mediates p38 MAPK activation
Drugs		Dexfosfoserine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Body mass index ( 29273807) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Metabolic syndrome ( 31589552) Schizophrenia ( 28991256 25056061 29483656 30285260)	Body mass index ( 26426971 28892062)
Interacting Genes		12 interacting genes: BCKDK ELK1 KLHL12 MAP2K3 MAP2K6 MEGF10 RCHY1 TLE3 TUBA1A TUBA4A TUBB USF1	55 interacting genes: AKT1 ALDOC APP ARAF ARRB1 AURKA BECN1 BRAF CBLC CCND2 CD44 CDC42 CDK4 CDK6 CDKN2B CDKN2C DCTN1 DYRK1B ELK1 ERBB2 FZR1 GLIS2 HIF1A KAT2A KDELR2 LATS2 LRRK2 MAP2K5 MAP2K6 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAPK12 MAPK14 MAPK3 MAPK8IP2 MET NF1 NF2 NFIC PLCB2 PTEN RAF1 RASSF1 RPL13 SMAD1 SMAD7 STK11 TAOK1 TAOK2 TEAD2 TERT TINF2 TP53
Entrez ID		9344	5606
HPRD ID		18147	03816
Ensembl ID		ENSG00000149930	ENSG00000034152
Uniprot IDs		Q9UL54	P46734 Q6FI23
PDB IDs
Enriched GO Terms of Interacting Partners?
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