SHKBP1 and SH3KBP1

Number of citations of the paper that reports this interaction (PubMedID 11152963)
15

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		SHKBP1	SH3KBP1
Description		SH3KBP1 binding protein 1	SH3 domain containing kinase binding protein 1
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GO Annotations	Cellular Component	Lysosome	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Endocytic Vesicle Cytoplasmic Vesicle Membrane Neuron Projection Synapse
	Molecular Function	Protein Binding	Protein Binding SH3 Domain Binding
	Biological Process	Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Homooligomerization	Endocytosis Apoptotic Process Cytoskeleton Organization Actin Filament Organization Cell-cell Signaling Axon Guidance Regulation Of Cell Shape Cell Migration Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of B Cell Activation Membrane Organization
Pathways			EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Reelin signalling pathway InlB-mediated entry of Listeria monocytogenes into host cell Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
GWAS		Cleft lip with or without cleft palate x maternal periconceptional smoking interaction (parent of origin effect) ( 31372216)
Interacting Genes		8 interacting genes: CCNG1 COL7A1 CUL3 GRB2 NR3C1 PIN1 SH3KBP1 YWHAG	44 interacting genes: ABI2 ARAP3 ARHGAP27 ASAP1 ASAP2 BCAR1 BLNK BMPR1B CAPZA1 CBL CBLB CD2 GRB2 HCK INPP5D ITSN2 MVB12A NEDD4 PAK2 PDCD6 PDCD6IP PIK3CA PIK3R1 PNMA5 PSMA3 SEPTIN2 SEPTIN6 SH3BP2 SH3GL2 SH3GL3 SH3GLB1 SH3GLB2 SHKBP1 SOS1 SPRY2 STAP1 SYNJ1 TAF6 TJP2 UBB UBC UBE2I ZBTB7B ZNF219
Entrez ID		92799	30011
HPRD ID		15338	02301
Ensembl ID		ENSG00000160410	ENSG00000147010
Uniprot IDs		B3KVX8 Q8TBC3	B7Z6E8 Q5JPT6 Q96B97
PDB IDs		4CRH	2BZ8 2K6D 2K9G 2N64 2O2O 2YDL 5ABS
Enriched GO Terms of Interacting Partners?
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