CRLF1 and CLCF1

Number of citations of the paper that reports this interaction (PubMedID 10966616)
70

Data Source:
HPRD (in vitro, in vivo)

		CRLF1	CLCF1
Description		cytokine receptor like factor 1	cardiotrophin like cytokine factor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol External Side Of Plasma Membrane Receptor Complex CRLF-CLCF1 Complex	Extracellular Region CRLF-CLCF1 Complex CNTFR-CLCF1 Complex
	Molecular Function	Cytokine Receptor Activity Cytokine Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Cytokine Binding	Signaling Receptor Binding Cytokine Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Ureteric Bud Development Positive Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Neuron Apoptotic Process Interleukin-27-mediated Signaling Pathway Negative Regulation Of Motor Neuron Apoptotic Process	Positive Regulation Of Immunoglobulin Production Cell Surface Receptor Signaling Pathway JAK-STAT Cascade Positive Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway B Cell Differentiation Positive Regulation Of B Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Isotype Switching To IgE Isotypes Positive Regulation Of Astrocyte Differentiation
Pathways		IL-6-type cytokine receptor ligand interactions Interleukin-27 signaling	IL-6-type cytokine receptor ligand interactions
Drugs
Diseases		Cold-induced sweating syndrome (CISS) and Crisponi syndrome (CRISPS)	Cold-induced sweating syndrome (CISS) and Crisponi syndrome (CRISPS)
GWAS		Blood protein levels ( 30072576) Dentures ( 31235808) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Metabolite levels (lipid measures) ( 27005778)
Interacting Genes		2 interacting genes: CLCF1 CNTFR	2 interacting genes: CNTFR CRLF1
Entrez ID		9244	23529
HPRD ID		09177	09643
Ensembl ID		ENSG00000006016	ENSG00000175505
Uniprot IDs		O75462	Q9UBD9
PDB IDs
Enriched GO Terms of Interacting Partners?
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