CLCF1 and CRLF1

Number of citations of the paper that reports this interaction (PubMedID 10966616)
70

Data Source:
HPRD (in vitro, in vivo)

		CLCF1	CRLF1
Description		cardiotrophin like cytokine factor 1	cytokine receptor like factor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region CRLF-CLCF1 Complex CNTFR-CLCF1 Complex	Extracellular Region Extracellular Space Cytosol External Side Of Plasma Membrane Receptor Complex CRLF-CLCF1 Complex
	Molecular Function	Signaling Receptor Binding Cytokine Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Growth Factor Activity	Cytokine Receptor Activity Cytokine Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Cytokine Binding
	Biological Process	Positive Regulation Of Immunoglobulin Production Cell Surface Receptor Signaling Pathway JAK-STAT Cascade Positive Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway B Cell Differentiation Positive Regulation Of B Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Isotype Switching To IgE Isotypes Positive Regulation Of Astrocyte Differentiation	Ureteric Bud Development Positive Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Neuron Apoptotic Process Interleukin-27-mediated Signaling Pathway Negative Regulation Of Motor Neuron Apoptotic Process
Pathways		IL-6-type cytokine receptor ligand interactions	IL-6-type cytokine receptor ligand interactions Interleukin-27 signaling
Drugs
Diseases		Cold-induced sweating syndrome (CISS) and Crisponi syndrome (CRISPS)	Cold-induced sweating syndrome (CISS) and Crisponi syndrome (CRISPS)
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Metabolite levels (lipid measures) ( 27005778)	Blood protein levels ( 30072576) Dentures ( 31235808) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808)
Interacting Genes		2 interacting genes: CNTFR CRLF1	2 interacting genes: CLCF1 CNTFR
Entrez ID		23529	9244
HPRD ID		09643	09177
Ensembl ID		ENSG00000175505	ENSG00000006016
Uniprot IDs		Q9UBD9	O75462
PDB IDs
Enriched GO Terms of Interacting Partners?
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