CLCF1 and CNTFR

Number of citations of the paper that reports this interaction (PubMedID 10966616)
70

Data Source:
HPRD (in vivo, in vitro)

		CLCF1	CNTFR
Description		cardiotrophin like cytokine factor 1	ciliary neurotrophic factor receptor
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region CRLF-CLCF1 Complex CNTFR-CLCF1 Complex	Plasma Membrane External Side Of Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Receptor Complex Ciliary Neurotrophic Factor Receptor Complex CNTFR-CLCF1 Complex
	Molecular Function	Signaling Receptor Binding Cytokine Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Growth Factor Activity	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Signaling Receptor Binding Protein Binding Cytokine Binding
	Biological Process	Positive Regulation Of Immunoglobulin Production Cell Surface Receptor Signaling Pathway JAK-STAT Cascade Positive Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway B Cell Differentiation Positive Regulation Of B Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Isotype Switching To IgE Isotypes Positive Regulation Of Astrocyte Differentiation	Suckling Behavior Brainstem Development Signal Transduction Nervous System Development Sex Differentiation Positive Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Skeletal Muscle Organ Development Ciliary Neurotrophic Factor-mediated Signaling Pathway
Pathways		IL-6-type cytokine receptor ligand interactions	IL-6-type cytokine receptor ligand interactions
Drugs
Diseases		Cold-induced sweating syndrome (CISS) and Crisponi syndrome (CRISPS)
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Metabolite levels (lipid measures) ( 27005778)	Blood protein levels ( 30072576 29875488)
Interacting Genes		2 interacting genes: CNTFR CRLF1	9 interacting genes: APPBP2 CLCF1 CNTF CRLF1 IL6ST JPT2 KRTAP4-12 LIFR PLSCR1
Entrez ID		23529	1271
HPRD ID		09643	00348
Ensembl ID		ENSG00000175505	ENSG00000122756
Uniprot IDs		Q9UBD9	P26992
PDB IDs			1UC6
Enriched GO Terms of Interacting Partners?
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