PDCD5 and GGCX

		PDCD5	GGCX
Description		programmed cell death 5	gamma-glutamyl carboxylase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	DNA Binding Protein Binding Heparin Binding Acetyltransferase Activator Activity Beta-tubulin Binding	Gamma-glutamyl Carboxylase Activity Vitamin Binding
	Biological Process	Apoptotic Process Negative Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Protein Import Into Mitochondrial Outer Membrane Negative Regulation Of Chaperone-mediated Protein Folding	Cellular Protein Modification Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation
Pathways			Gamma-carboxylation of protein precursors Gamma-carboxylation of protein precursors
Drugs			Coagulation factor VIIa Recombinant Human Drotrecogin alfa Coagulation Factor IX (Recombinant) Glutamic Acid Menadione Phylloquinone Anisindione Coagulation Factor IX Human
Diseases			Pseudoxanthoma elasticum, including: Pseudoxanthoma elasticum (PXE); Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS		Blood protein levels ( 30072576 29875488) Major depressive disorder ( 23377640) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Mean platelet volume ( 27863252) Metabolite levels ( 23823483) Red cell distribution width ( 27863252)	Coronary artery disease ( 29212778 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Myocardial infarction ( 26343387) Prostate cancer ( 21743467)
Interacting Genes		12 interacting genes: ACP5 CEP126 EEF1G GGCX KAT5 KDM1A LRIF1 NUDT3 OTUD5 UBE2D3 UTP14A VHL	14 interacting genes: ARFGAP1 ATP2C1 BGLAP CD8A F10 F2 F7 F9 FXN PDCD5 PPM1G PROC SRPK2 ST3GAL4
Entrez ID		9141	2677
HPRD ID		06843	00665
Ensembl ID		ENSG00000105185	ENSG00000115486
Uniprot IDs		O14737	P38435
PDB IDs		1YYB 2CRU 2K6B
Enriched GO Terms of Interacting Partners?
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