UBE2M and RNF111

Number of citations of the paper that reports this interaction (PubMedID 19549727)
67

Data Source:
BioGRID (two hybrid)

		UBE2M	RNF111
Description		ubiquitin conjugating enzyme E2 M	ring finger protein 111
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GO Annotations	Cellular Component	Nucleoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body Protein-containing Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding NEDD8 Transferase Activity Ubiquitin Conjugating Enzyme Activity	Protein Binding SUMO Polymer Binding SMAD Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Cellular Protein Modification Process Protein Ubiquitination Positive Regulation Of Neuron Apoptotic Process Post-translational Protein Modification Protein Neddylation	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Pattern Specification Process Protein Ubiquitination Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Global Genome Nucleotide-excision Repair
Pathways		TGF-beta receptor signaling activates SMADs Dectin-1 mediated noncanonical NF-kB signaling NIK - noncanonical NF-kB signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Formation of Incision Complex in GG-NER Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Asperger disorder ( 21182207) Atopic dermatitis ( 25865352) Cerebrospinal fluid AB1-42 levels ( 28247064) Metabolite levels ( 22916037) Social communication problems ( 24047820)
Interacting Genes		28 interacting genes: APP CAND1 CBL CPNE1 CPNE2 CPNE4 CUL1 CUL7 DCUN1D1 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 FBXO7 ITCH MARCHF7 NEDD4 NEDD8 PINK1 PRKN RBX1 RNF111 RNF7 SENP8 SMURF1 TERF1 TP53 UBA3	44 interacting genes: ACTN3 ANAPC11 AXIN1 CREB1 CREBBP CSNK2A1 CTBP1 DTX3L EDARADD FBN1 KRTAP5-9 LCE4A LRSAM1 MARCHF7 MVP PHF7 PML SMAD3 SMAD6 SMAD7 SMURF2 SUMO1 SUMO2 SUMO3 TRAF5 TRIM21 TRIM8 TSG101 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2I UBE2K UBE2M UBE2N UBE2Q2 UBE2V1 UBE2W
Entrez ID		9040	54778
HPRD ID		04414	09318
Ensembl ID		ENSG00000130725	ENSG00000157450
Uniprot IDs		A0A024R4T4 P61081	A0A024R5T5 Q6ZNA4
PDB IDs		1TT5 1Y8X 2NVU 3TDU 3TDZ 4GAO 4P5O	2KIZ 5LG0 5LG7
Enriched GO Terms of Interacting Partners?
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