RNF111 and ACTN3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		RNF111	ACTN3
Description		ring finger protein 111	actinin alpha 3 (gene/pseudogene)
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body Protein-containing Complex	Cytosol Actin Filament Focal Adhesion Pseudopodium Extracellular Exosome
	Molecular Function	Protein Binding SUMO Polymer Binding SMAD Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Ion Channel Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Pattern Specification Process Protein Ubiquitination Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Global Genome Nucleotide-excision Repair	Regulation Of The Force Of Skeletal Muscle Contraction Skeletal Muscle Atrophy Transition Between Fast And Slow Fiber Response To Denervation Involved In Regulation Of Muscle Adaptation Muscle Filament Sliding Regulation Of Apoptotic Process Negative Regulation Of Glycolytic Process Focal Adhesion Assembly Positive Regulation Of Skeletal Muscle Tissue Growth Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Oxidative Phosphorylation Negative Regulation Of Cold-induced Thermogenesis Regulation Of Aerobic Respiration Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate
Pathways		Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Formation of Incision Complex in GG-NER Antigen processing: Ubiquitination & Proteasome degradation	Nephrin family interactions Striated Muscle Contraction
Drugs
Diseases
GWAS		Asperger disorder ( 21182207) Atopic dermatitis ( 25865352) Cerebrospinal fluid AB1-42 levels ( 28247064) Metabolite levels ( 22916037) Social communication problems ( 24047820)	Bipolar disorder ( 21926972) Frontotemporal dementia with GRN mutation ( 29724592)
Interacting Genes		44 interacting genes: ACTN3 ANAPC11 AXIN1 CREB1 CREBBP CSNK2A1 CTBP1 DTX3L EDARADD FBN1 KRTAP5-9 LCE4A LRSAM1 MARCHF7 MVP PHF7 PML SMAD3 SMAD6 SMAD7 SMURF2 SUMO1 SUMO2 SUMO3 TRAF5 TRIM21 TRIM8 TSG101 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2I UBE2K UBE2M UBE2N UBE2Q2 UBE2V1 UBE2W	17 interacting genes: ABI3 ACTN1 ACTN2 ACTN4 ADORA2A BRCA1 C1orf94 KCTD6 MYPN NEBL NRAP PLEKHG2 REL RNF111 SUMO1P1 TRAF1 TRAF2
Entrez ID		54778	89
HPRD ID		09318	02148
Ensembl ID		ENSG00000157450	ENSG00000248746
Uniprot IDs		A0A024R5T5 Q6ZNA4	A0A087WSZ2 B4DZQ2 Q08043
PDB IDs		2KIZ 5LG0 5LG7	1TJT 1WKU 3LUE
Enriched GO Terms of Interacting Partners?
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