CHRNA6 and PPP3R1

Number of citations of the paper that reports this interaction (PubMedID 27107012)
28

Data Source:
BioGRID (two hybrid)

		CHRNA6	PPP3R1
Description		cholinergic receptor nicotinic alpha 6 subunit	protein phosphatase 3 regulatory subunit B, alpha
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Cell Junction Neuron Projection Synapse Dopaminergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane	Nucleoplasm Mitochondrion Cytosol Calcineurin Complex Sarcolemma
	Molecular Function	Protein Binding Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Acetylcholine Binding	Calcium-dependent Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Cyclosporin A Binding Phosphatase Binding Protein Domain Specific Binding
	Biological Process	Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Regulation Of Dopamine Secretion Ion Transmembrane Transport Response To Nicotine Regulation Of Membrane Potential Nervous System Process Membrane Depolarization Excitatory Postsynaptic Potential Regulation Of Synaptic Vesicle Exocytosis	Protein Dephosphorylation Wnt Signaling Pathway, Calcium Modulating Pathway Calcineurin-NFAT Signaling Cascade Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors	Activation of BAD and translocation to mitochondria DARPP-32 events Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation
Drugs		Nicotine Galantamine Ethanol Varenicline Cytisine	Myristic acid Voclosporin
Diseases
GWAS		Nicotine dependence ( 26440539) Pelvic organ prolapse (moderate/severe) ( 26545240) Smoking behavior ( 20418888)	General cognitive ability ( 29844566) Height ( 25282103) Intelligence (MTAG) ( 29326435) Schizophrenia ( 30285260) Urinary potassium excretion ( 31409800)
Interacting Genes		1 interacting genes: PPP3R1	9 interacting genes: CABP1 CABP2 CABP5 CHRNA6 MAP3K5 NAP1L2 NFATC1 NFATC2 PPP3CA
Entrez ID		8973	5534
HPRD ID		06056	03195
Ensembl ID		ENSG00000147434	ENSG00000221823
Uniprot IDs		Q15825	P63098
PDB IDs			1AUI 1M63 1MF8 2P6B 3LL8 4F0Z 4OR9 4ORA 4ORC 5SVE 6NUC 6NUF 6NUU
Enriched GO Terms of Interacting Partners?
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