PPP3R1 and CHRNA6

Number of citations of the paper that reports this interaction (PubMedID 27107012)
28

Data Source:
BioGRID (two hybrid)

		PPP3R1	CHRNA6
Description		protein phosphatase 3 regulatory subunit B, alpha	cholinergic receptor nicotinic alpha 6 subunit
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Cytosol Calcineurin Complex Sarcolemma	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Cell Junction Neuron Projection Synapse Dopaminergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane
	Molecular Function	Calcium-dependent Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Cyclosporin A Binding Phosphatase Binding Protein Domain Specific Binding	Protein Binding Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Acetylcholine Binding
	Biological Process	Protein Dephosphorylation Wnt Signaling Pathway, Calcium Modulating Pathway Calcineurin-NFAT Signaling Cascade Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Regulation Of Dopamine Secretion Ion Transmembrane Transport Response To Nicotine Regulation Of Membrane Potential Nervous System Process Membrane Depolarization Excitatory Postsynaptic Potential Regulation Of Synaptic Vesicle Exocytosis
Pathways		Activation of BAD and translocation to mitochondria DARPP-32 events Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
Drugs		Myristic acid Voclosporin	Nicotine Galantamine Ethanol Varenicline Cytisine
Diseases
GWAS		General cognitive ability ( 29844566) Height ( 25282103) Intelligence (MTAG) ( 29326435) Schizophrenia ( 30285260) Urinary potassium excretion ( 31409800)	Nicotine dependence ( 26440539) Pelvic organ prolapse (moderate/severe) ( 26545240) Smoking behavior ( 20418888)
Interacting Genes		9 interacting genes: CABP1 CABP2 CABP5 CHRNA6 MAP3K5 NAP1L2 NFATC1 NFATC2 PPP3CA	1 interacting genes: PPP3R1
Entrez ID		5534	8973
HPRD ID		03195	06056
Ensembl ID		ENSG00000221823	ENSG00000147434
Uniprot IDs		P63098	Q15825
PDB IDs		1AUI 1M63 1MF8 2P6B 3LL8 4F0Z 4OR9 4ORA 4ORC 5SVE 6NUC 6NUF 6NUU
Enriched GO Terms of Interacting Partners?
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