ACTN1 and KCTD6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ACTN1	KCTD6
Description		actinin alpha 1	potassium channel tetramerization domain containing 6
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Ruffle Extracellular Region Extracellular Space Cytoplasm Cytosol Actin Filament Plasma Membrane Brush Border Cell-cell Junction Fascia Adherens Focal Adhesion Z Disc Platelet Alpha Granule Lumen Pseudopodium Cell Projection Extracellular Exosome Glutamatergic Synapse	Cytosol M Band
	Molecular Function	Double-stranded RNA Binding Integrin Binding Calcium Ion Binding Protein Binding Vinculin Binding Nuclear Receptor Transcription Coactivator Activity Protein Homodimerization Activity Ion Channel Binding Actin Filament Binding Structural Constituent Of Postsynapse	Protein Binding Ankyrin Binding Identical Protein Binding Cullin Family Protein Binding
	Biological Process	Platelet Degranulation Actin Filament Organization Platelet Activation Platelet Formation Platelet Morphogenesis Regulation Of Apoptotic Process Focal Adhesion Assembly Actin Filament Bundle Assembly Negative Regulation Of Cellular Component Movement Actin Filament Network Formation Actin Crosslink Formation Platelet Aggregation Postsynapse Organization Positive Regulation Of Nucleic Acid-templated Transcription	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Growth Post-translational Protein Modification Negative Regulation Of Smoothened Signaling Pathway Protein Homooligomerization
Pathways		Platelet degranulation Syndecan interactions Nephrin family interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	RUNX1 regulates estrogen receptor mediated transcription Neddylation Estrogen-dependent gene expression Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Copper
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Feeling fed-up ( 29500382) Feeling hurt ( 29500382) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) Lack of perseverance ( 30718321) Mean platelet volume ( 27863252) Medication use (drugs used in diabetes) ( 31015401) Mosquito bite size ( 28199695) Neurociticism ( 29500382) Periodontitis (Mean PAL) ( 24024966) Platelet count ( 26805783 29403010) Platelet distribution width ( 27863252) Prostate cancer ( 23535732) Rheumatoid arthritis (ACPA-positive) ( 23143596) Smoking behavior ( 19247474) Urinary albumin excretion ( 30220432)	Hepcidin/transferrin saturation ratio ( 27846281) Systemic lupus erythematosus ( 28714469) vWF levels ( 30586737)
Interacting Genes		79 interacting genes: ACTN2 ACTN3 ADORA2A APC ATXN2 ATXN7 CACNA1A CAMK2A CBY2 CDK5 CDK5R1 CDK5R2 CLIC5 COIL COL17A1 CSRP1 CSRP3 CTNNA1 DDIAS EPM2AIP1 ERBIN FBP1 FXN GFI1B GIPC1 GIT2 GRIA4 GRIN2A GRM5 GTF2H1 HSPB1 ICAM5 ITGB1 KAT2B KCTD6 KPNA2 LPP MAGEA11 MAP2 MAP3K1 MED14 MICALL2 MTDH MTNR1A MTNR1B MYOT MYOZ1 MYOZ2 MYOZ3 NEBL NR1H3 NUMBL OAS1 PALLD PDHX PDLIM1 PDLIM5 PIAS4 PKD1 PKN1 PLD2 PSEN1 PSMA1 PTK2 PTPN1 PTPN6 PYGB RAVER1 RPS27 SIRPA SLC2A4 SORBS2 SRC SSX2IP TES TTN VCL XRCC4 ZYX	17 interacting genes: ACTN1 ACTN3 ANK1 C8orf33 CDC23 CTNND1 EHHADH FAM124B GOLGA8EP GOLGA8F GRB7 GSDMD LNX1 PPIG PRPF31 SDCBP ZCCHC10
Entrez ID		87	200845
HPRD ID		00020	13769
Ensembl ID		ENSG00000072110	ENSG00000168301
Uniprot IDs		A0A024R694 P12814	Q8NC69
PDB IDs		2EYI 2EYN 2N8Y 2N8Z
Enriched GO Terms of Interacting Partners?
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