ACTN1 and FXN

Number of citations of the paper that reports this interaction (PubMedID 16713569)
313

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ACTN1	FXN
Description		actinin alpha 1	frataxin
Image
GO Annotations	Cellular Component	Stress Fiber Ruffle Extracellular Region Extracellular Space Cytoplasm Cytosol Actin Filament Plasma Membrane Brush Border Cell-cell Junction Fascia Adherens Focal Adhesion Z Disc Platelet Alpha Granule Lumen Pseudopodium Cell Projection Extracellular Exosome Glutamatergic Synapse	Cell Mitochondrion Mitochondrial Matrix Cytosol L-cysteine Desulfurase Complex
	Molecular Function	Double-stranded RNA Binding Integrin Binding Calcium Ion Binding Protein Binding Vinculin Binding Nuclear Receptor Transcription Coactivator Activity Protein Homodimerization Activity Ion Channel Binding Actin Filament Binding Structural Constituent Of Postsynapse	Ferroxidase Activity Protein Binding Ferrous Iron Binding Ferric Iron Binding Iron Chaperone Activity 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Platelet Degranulation Actin Filament Organization Platelet Activation Platelet Formation Platelet Morphogenesis Regulation Of Apoptotic Process Focal Adhesion Assembly Actin Filament Bundle Assembly Negative Regulation Of Cellular Component Movement Actin Filament Network Formation Actin Crosslink Formation Platelet Aggregation Postsynapse Organization Positive Regulation Of Nucleic Acid-templated Transcription	Oxidative Phosphorylation Heme Biosynthetic Process Ion Transport Cellular Iron Ion Homeostasis Mitochondrion Organization Adult Walking Behavior Positive Regulation Of Cell Proliferation Aerobic Respiration Embryo Development Ending In Birth Or Egg Hatching Response To Iron Ion Regulation Of Ferrochelatase Activity Iron-sulfur Cluster Assembly Protein Autoprocessing Iron Incorporation Into Metallo-sulfur Cluster Proprioception Positive Regulation Of Cell Growth Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Small Molecule Metabolic Process Negative Regulation Of Organ Growth Positive Regulation Of Lyase Activity Cellular Response To Hydrogen Peroxide Negative Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Succinate Dehydrogenase Activity Positive Regulation Of Aconitate Hydratase Activity
Pathways		Platelet degranulation Syndecan interactions Nephrin family interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	Mitochondrial protein import Mitochondrial protein import Mitochondrial iron-sulfur cluster biogenesis
Drugs		Copper	Iron
Diseases			Friedreich ataxia
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Feeling fed-up ( 29500382) Feeling hurt ( 29500382) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) Lack of perseverance ( 30718321) Mean platelet volume ( 27863252) Medication use (drugs used in diabetes) ( 31015401) Mosquito bite size ( 28199695) Neurociticism ( 29500382) Periodontitis (Mean PAL) ( 24024966) Platelet count ( 26805783 29403010) Platelet distribution width ( 27863252) Prostate cancer ( 23535732) Rheumatoid arthritis (ACPA-positive) ( 23143596) Smoking behavior ( 19247474) Urinary albumin excretion ( 30220432)	Headache ( 29397368) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Myopia ( 27182965) Night sleep phenotypes ( 27126917) Seasonality ( 25562672)
Interacting Genes		79 interacting genes: ACTN2 ACTN3 ADORA2A APC ATXN2 ATXN7 CACNA1A CAMK2A CBY2 CDK5 CDK5R1 CDK5R2 CLIC5 COIL COL17A1 CSRP1 CSRP3 CTNNA1 DDIAS EPM2AIP1 ERBIN FBP1 FXN GFI1B GIPC1 GIT2 GRIA4 GRIN2A GRM5 GTF2H1 HSPB1 ICAM5 ITGB1 KAT2B KCTD6 KPNA2 LPP MAGEA11 MAP2 MAP3K1 MED14 MICALL2 MTDH MTNR1A MTNR1B MYOT MYOZ1 MYOZ2 MYOZ3 NEBL NR1H3 NUMBL OAS1 PALLD PDHX PDLIM1 PDLIM5 PIAS4 PKD1 PKN1 PLD2 PSEN1 PSMA1 PTK2 PTPN1 PTPN6 PYGB RAVER1 RPS27 SIRPA SLC2A4 SORBS2 SRC SSX2IP TES TTN VCL XRCC4 ZYX	5 interacting genes: ACTN1 GGCX PICK1 PMPCB RNF126
Entrez ID		87	2395
HPRD ID		00020	06013
Ensembl ID		ENSG00000072110	ENSG00000165060
Uniprot IDs		A0A024R694 P12814	A0A0S2Z3G4 Q16595
PDB IDs		2EYI 2EYN 2N8Y 2N8Z	1EKG 1LY7 3S4M 3S5D 3S5E 3S5F 3T3J 3T3K 3T3L 3T3T 3T3X 5KZ5 6NZU
Enriched GO Terms of Interacting Partners?
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