VAMP8 and STX4

Number of citations of the paper that reports this interaction (PubMedID 10820264)
62

Data Source:
HPRD (in vitro)

		VAMP8	STX4
Description		vesicle associated membrane protein 8	syntaxin 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Early Endosome Cytosol Plasma Membrane Membrane Integral Component Of Membrane Clathrin-coated Vesicle Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane SNARE Complex Early Endosome Membrane Late Endosome Membrane Vesicle Azurophil Granule Membrane Specific Granule Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Tertiary Granule Membrane Mucin Granule	Storage Vacuole Extracellular Space Endosome Vacuole Trans-Golgi Network Cytosol Plasma Membrane Synaptic Vesicle Cell Surface Endomembrane System Membrane Integral Component Of Membrane Basolateral Plasma Membrane Lamellipodium Phagocytic Vesicle Membrane SNARE Complex Myelin Sheath Adaxonal Region Somatodendritic Compartment Specific Granule Presynaptic Membrane Dendritic Spine Lateral Loop Synapse Perinuclear Region Of Cytoplasm Presynaptic Active Zone Membrane Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	SNAP Receptor Activity Protein Binding Chloride Channel Inhibitor Activity Syntaxin Binding	SNARE Binding SNAP Receptor Activity Protein Binding Sphingomyelin Phosphodiesterase Activator Activity
	Biological Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Post-Golgi Vesicle-mediated Transport Vesicle Fusion Protein Transport Autophagosome Membrane Docking SNARE Complex Assembly Eosinophil Degranulation Neutrophil Degranulation Viral Entry Into Host Cell Membrane Organization Mucus Secretion Autophagosome Maturation Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Secretion By Cell Positive Regulation Of Histamine Secretion By Mast Cell	Intracellular Protein Transport Exocytosis Post-Golgi Vesicle-mediated Transport Vesicle Fusion Positive Regulation Of Cell Proliferation Regulation Of Exocytosis Cytokine-mediated Signaling Pathway Positive Regulation Of Cell Migration Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Cellular Response To Oxidative Stress SNARE Complex Assembly Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Catalytic Activity Positive Regulation Of Eosinophil Degranulation Positive Regulation Of Cell Adhesion Vesicle Docking Organelle Fusion Positive Regulation Of Chemotaxis Positive Regulation Of Immunoglobulin Secretion Long-term Synaptic Potentiation Cellular Response To Interferon-gamma Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Protein Localization To Plasma Membrane Cornified Envelope Assembly Vesicle Fusion With Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membrane Positive Regulation Of Protein Localization To Cell Surface
Pathways		ER-Phagosome pathway trans-Golgi Network Vesicle Budding Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Neutrophil degranulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Disinhibition of SNARE formation ER-Phagosome pathway Translocation of SLC2A4 (GLUT4) to the plasma membrane trans-Golgi Network Vesicle Budding Other interleukin signaling
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Eosinophil counts ( 27863252) Myocardial infarction ( 26343387) Prostate cancer ( 21743467) Sum eosinophil basophil counts ( 27863252)	Response to metformin (IC50) ( 28173075)
Interacting Genes		12 interacting genes: CDC25A MLH1 NAPA SNAP23 SNAP25 STX1A STX3 STX4 STX7 UBE2G2 VAMP2 VAMP3	48 interacting genes: ACTB BET1 CYBRD1 DLG1 DNAJC5 EMD GIMAP5 GOSR2 ITSN2 LLGL1 LMNA NAPA NAPB NSF PSMA3 RAB11A RAB4A RAB5A SCRIB SEC22A SEPTIN5 SH3GLB2 SNAP23 SNAP25 SNAP29 SNAP47 STX16 STX3 STX5 STX8 STXBP3 STXBP4 STXBP5 STXBP6 SYT1 SYT4 SYT7 TXLNA TXLNB TXLNG VAMP1 VAMP2 VAMP3 VAMP4 VAMP7 VAMP8 VAPB VTI1B
Entrez ID		8673	6810
HPRD ID		04415	01722
Ensembl ID		ENSG00000118640	ENSG00000103496
Uniprot IDs		B8ZZT4 Q9BV40	B7Z425 Q12846
PDB IDs		4WY4
Enriched GO Terms of Interacting Partners?
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