STX4 and SEC22A

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		STX4	SEC22A
Description		syntaxin 4	SEC22 homolog A, vesicle trafficking protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Storage Vacuole Extracellular Space Endosome Vacuole Trans-Golgi Network Cytosol Plasma Membrane Synaptic Vesicle Cell Surface Endomembrane System Membrane Integral Component Of Membrane Basolateral Plasma Membrane Lamellipodium Phagocytic Vesicle Membrane SNARE Complex Myelin Sheath Adaxonal Region Somatodendritic Compartment Specific Granule Presynaptic Membrane Dendritic Spine Lateral Loop Synapse Perinuclear Region Of Cytoplasm Presynaptic Active Zone Membrane Extracellular Exosome Postsynapse Glutamatergic Synapse	Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Sphingomyelin Phosphodiesterase Activator Activity	Transporter Activity Protein Binding
	Biological Process	Intracellular Protein Transport Exocytosis Post-Golgi Vesicle-mediated Transport Vesicle Fusion Positive Regulation Of Cell Proliferation Regulation Of Exocytosis Cytokine-mediated Signaling Pathway Positive Regulation Of Cell Migration Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Cellular Response To Oxidative Stress SNARE Complex Assembly Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Catalytic Activity Positive Regulation Of Eosinophil Degranulation Positive Regulation Of Cell Adhesion Vesicle Docking Organelle Fusion Positive Regulation Of Chemotaxis Positive Regulation Of Immunoglobulin Secretion Long-term Synaptic Potentiation Cellular Response To Interferon-gamma Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Protein Localization To Plasma Membrane Cornified Envelope Assembly Vesicle Fusion With Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membrane Positive Regulation Of Protein Localization To Cell Surface	ER To Golgi Vesicle-mediated Transport Protein Transport
Pathways		Disinhibition of SNARE formation ER-Phagosome pathway Translocation of SLC2A4 (GLUT4) to the plasma membrane trans-Golgi Network Vesicle Budding Other interleukin signaling	COPII-mediated vesicle transport
Drugs
Diseases
GWAS		Response to metformin (IC50) ( 28173075)	Gestational age at birth (maternal effect) ( 28877031)
Interacting Genes		48 interacting genes: ACTB BET1 CYBRD1 DLG1 DNAJC5 EMD GIMAP5 GOSR2 ITSN2 LLGL1 LMNA NAPA NAPB NSF PSMA3 RAB11A RAB4A RAB5A SCRIB SEC22A SEPTIN5 SH3GLB2 SNAP23 SNAP25 SNAP29 SNAP47 STX16 STX3 STX5 STX8 STXBP3 STXBP4 STXBP5 STXBP6 SYT1 SYT4 SYT7 TXLNA TXLNB TXLNG VAMP1 VAMP2 VAMP3 VAMP4 VAMP7 VAMP8 VAPB VTI1B	11 interacting genes: DTX2 EDA ERLIN1 FATE1 LMNA MSR1 RNF5 SFTPC STX4 SYNE4 TMEM79
Entrez ID		6810	26984
HPRD ID		01722	15313
Ensembl ID		ENSG00000103496	ENSG00000121542
Uniprot IDs		B7Z425 Q12846	Q96IW7
PDB IDs
Enriched GO Terms of Interacting Partners?
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