IGSF21 and ANXA3

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		IGSF21	ANXA3
Description		immunoglobin superfamily member 21	annexin A3
Image		No pdb structure
GO Annotations	Cellular Component	Adherens Junction Anchored Component Of External Side Of Plasma Membrane Presynaptic Membrane Postsynaptic Membrane Inhibitory Synapse	Cytoplasm Cytosol Plasma Membrane Membrane Axon Dendrite Phagocytic Vesicle Membrane Specific Granule Neuronal Cell Body Extracellular Exosome
	Molecular Function	Signaling Receptor Activity Protein Homodimerization Activity Cell Adhesion Molecule Binding	Calcium Ion Binding Calcium-dependent Phospholipid Binding Calcium-dependent Protein Binding
	Biological Process	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Synapse Maturation	Phagocytosis Positive Regulation Of Endothelial Cell Migration Hippocampus Development Animal Organ Regeneration Defense Response To Bacterium Negative Regulation Of Catalytic Activity Neutrophil Degranulation Positive Regulation Of Angiogenesis Positive Regulation Of DNA Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Response To Growth Factor
Pathways
Drugs			Ethanolamine Difluocortolone
Diseases
GWAS		Atypical femoral fracture in phosphonate treatment ( 31006051) Cobalt levels ( 26025379) Diabetic retinopathy ( 21441570) Erectile dysfunction and prostate cancer treatment ( 20932654) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Pre-treatment viral load in HIV-1 infection ( 31219150) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Serum bilirubin levels x sex interaction in metabolic syndrome ( 30621171) Survival in pancreatic cancer ( 28470677)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Metabolite levels ( 23823483) Non-albumin protein levels ( 22558069) Rheumatoid arthritis ( 30423114 22446963)
Interacting Genes		32 interacting genes: ALDH2 ANXA3 ATF3 BCR BTBD2 CRCT1 DGKD EPB41L3 ERH ETHE1 GADD45A GIPC2 GSK3B GSTM4 HSPB1 KRAS MAD2L1BP NACA NREP PAEP PAFAH1B3 PCDHA4 PRMT1 PSMD11 RPP14 S100A8 SEPHS1 SERPINB9 SULT1E1 TMSB4X TRBV2 UBE2V2	7 interacting genes: BAG5 EMG1 IGSF21 REG3A TP53 UBR1 UNC119
Entrez ID		84966	306
HPRD ID		11309	00111
Ensembl ID		ENSG00000117154	ENSG00000138772
Uniprot IDs		Q96ID5	P12429
PDB IDs			1AII 1AXN
Enriched GO Terms of Interacting Partners?
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