ANXA3 and IGSF21

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ANXA3	IGSF21
Description		annexin A3	immunoglobin superfamily member 21
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Axon Dendrite Phagocytic Vesicle Membrane Specific Granule Neuronal Cell Body Extracellular Exosome	Adherens Junction Anchored Component Of External Side Of Plasma Membrane Presynaptic Membrane Postsynaptic Membrane Inhibitory Synapse
	Molecular Function	Calcium Ion Binding Calcium-dependent Phospholipid Binding Calcium-dependent Protein Binding	Signaling Receptor Activity Protein Homodimerization Activity Cell Adhesion Molecule Binding
	Biological Process	Phagocytosis Positive Regulation Of Endothelial Cell Migration Hippocampus Development Animal Organ Regeneration Defense Response To Bacterium Negative Regulation Of Catalytic Activity Neutrophil Degranulation Positive Regulation Of Angiogenesis Positive Regulation Of DNA Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Response To Growth Factor	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Synapse Maturation
Pathways
Drugs		Ethanolamine Difluocortolone
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Metabolite levels ( 23823483) Non-albumin protein levels ( 22558069) Rheumatoid arthritis ( 30423114 22446963)	Atypical femoral fracture in phosphonate treatment ( 31006051) Cobalt levels ( 26025379) Diabetic retinopathy ( 21441570) Erectile dysfunction and prostate cancer treatment ( 20932654) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Pre-treatment viral load in HIV-1 infection ( 31219150) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Serum bilirubin levels x sex interaction in metabolic syndrome ( 30621171) Survival in pancreatic cancer ( 28470677)
Interacting Genes		7 interacting genes: BAG5 EMG1 IGSF21 REG3A TP53 UBR1 UNC119	32 interacting genes: ALDH2 ANXA3 ATF3 BCR BTBD2 CRCT1 DGKD EPB41L3 ERH ETHE1 GADD45A GIPC2 GSK3B GSTM4 HSPB1 KRAS MAD2L1BP NACA NREP PAEP PAFAH1B3 PCDHA4 PRMT1 PSMD11 RPP14 S100A8 SEPHS1 SERPINB9 SULT1E1 TMSB4X TRBV2 UBE2V2
Entrez ID		306	84966
HPRD ID		00111	11309
Ensembl ID		ENSG00000138772	ENSG00000117154
Uniprot IDs		P12429	Q96ID5
PDB IDs		1AII 1AXN
Enriched GO Terms of Interacting Partners?
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