ZNF587 and CARD9

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ZNF587	CARD9
Description		zinc finger protein 587	caspase recruitment domain family member 9
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Cytoplasm Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	DNA Binding Protein Binding Metal Ion Binding	Protein Binding Protein Homodimerization Activity CARD Domain Binding
	Biological Process	Regulation Of Transcription, DNA-templated	Stimulatory C-type Lectin Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Response To Fungus Response To Peptidoglycan Response To Muramyl Dipeptide Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Exogenous DsRNA Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of JNK Cascade Defense Response To Gram-positive Bacterium Defense Response To Virus
Pathways		Generic Transcription Pathway	NOD1/2 Signaling Pathway CLEC7A (Dectin-1) signaling
Drugs
Diseases			Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS		Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444)	Acute insulin response (insulin secretion adjusted) ( 28490609) Ankylosing spondylitis ( 23749187 21743469) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 22936669 21102463) IgA nephropathy ( 25305756) Inflammatory bowel disease ( 28067908 23128233) Joint damage in rheumatoid arthritis ( 26498133) Large artery stroke ( 28265093) Monocyte chemoattractant protein-1 levels ( 23017229) Obesity-related traits ( 23251661) Pediatric autoimmune diseases ( 26301688) Ulcerative colitis ( 19915572 28067908 20228799 21297633)
Interacting Genes		43 interacting genes: ADAMTSL4 CARD9 CCDC136 CEP44 CEP70 CSRNP1 FSD2 GOLGA2 GOPC HMBOX1 KRT38 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP2-4 KRTAP5-9 MDFI MEOX2 MID2 MTUS2 NOTCH2NLA PLSCR1 PNMA2 PRPF31 RUNDC3A SMAD9 SPRY2 SSX2IP STX11 TCF4 TMCC2 TNS2 TRAF1 TRIM36 TRIM41 TRIM54 TSGA10 ZBTB8A ZNF417	69 interacting genes: ABLIM1 AMOTL2 AXIN1 BCL10 BLZF1 C1orf94 C2CD6 CCDC85B CCHCR1 CDCA7L CEP57L1 CEP70 CSNK2A1 CWF19L2 DAXX DUSP13 DVL2 EIF4E2 FAM124B FAM161A FAM50B HMBOX1 IHO1 IQCE KCTD9 KIAA0408 KIF9 KRT19 KRT31 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-5 LENG1 LMO1 LZTS2 MEOX2 MFAP1 NECAB2 PAK5 PBX2 PHC2 PNMA5 PPP1R18 RTP5 SSX2IP STX11 SUMO1 TASOR2 TCEANC TCL1A TFIP11 TLE5 TNFAIP1 TRIM23 TRIM29 TRIM42 TRIM54 TRIM62 TSNAX USP15 VPS28 ZCCHC7 ZNF250 ZNF417 ZNF572 ZNF587 ZNF655 ZNF688
Entrez ID		84914	64170
HPRD ID		15864	06236
Ensembl ID		ENSG00000198466	ENSG00000187796
Uniprot IDs		Q96SQ5	A0A024R8F1 Q9H257
PDB IDs			6E25 6E26 6E27 6E28 6N2M 6N2P
Enriched GO Terms of Interacting Partners?
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