COL25A1 and IAPP

Number of citations of the paper that reports this interaction (PubMedID 15522881)
8

Data Source:
HPRD (in vitro)

		COL25A1	IAPP
Description		collagen type XXV alpha 1 chain	islet amyloid polypeptide
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Cell Neuronal Cell Body
	Molecular Function	Amyloid-beta Binding Heparin Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength	Amyloid-beta Binding Signaling Receptor Binding Hormone Activity Protein Binding Identical Protein Binding
	Biological Process	Axonogenesis Involved In Innervation	Apoptotic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Positive Regulation Of Protein Kinase A Signaling Negative Regulation Of Mitochondrion Organization Sensory Perception Of Pain Negative Regulation Of Protein Complex Assembly Eating Behavior Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Cellular Protein Metabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Bone Resorption Positive Regulation Of Protein Kinase B Signaling Amylin Receptor Signaling Pathway Negative Regulation Of Amyloid Fibril Formation
Pathways		Collagen degradation Collagen biosynthesis and modifying enzymes Collagen chain trimerization	Regulation of gene expression in beta cells G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production Amyloid fiber formation
Drugs			Copper
Diseases
GWAS		Body mass index ( 25133637) Carotid plaque burden ( 28282560) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Height ( 28552196) Late-onset Alzheimer's disease ( 27770636) Schizophrenia (age at onset) ( 21688384) Systemic lupus erythematosus ( 21408207)	Diisocyanate-induced asthma ( 25918132)
Interacting Genes		3 interacting genes: APP IAPP SNCA	6 interacting genes: COL25A1 PCSK1 PCSK2 PDX1 RAMP1 RAMP2
Entrez ID		84570	3375
HPRD ID		09886	01005
Ensembl ID		ENSG00000188517	ENSG00000121351
Uniprot IDs		A0A2R8Y760 A8MWQ5 Q9BXS0	A0A024RAU1 P10997
PDB IDs			1KUW 2G48 2KB8 2L86 3DG1 3FPO 3FR1 3FTH 3FTK 3FTL 3FTR 3G7V 3G7W 3HGZ 5K5G 5KNZ 5KO0 5MGQ
Enriched GO Terms of Interacting Partners?
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