IAPP and COL25A1

Number of citations of the paper that reports this interaction (PubMedID 15522881)
8

Data Source:
HPRD (in vitro)

		IAPP	COL25A1
Description		islet amyloid polypeptide	collagen type XXV alpha 1 chain
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Neuronal Cell Body	Extracellular Region Collagen Trimer Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Collagen-containing Extracellular Matrix
	Molecular Function	Amyloid-beta Binding Signaling Receptor Binding Hormone Activity Protein Binding Identical Protein Binding	Amyloid-beta Binding Heparin Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Apoptotic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Positive Regulation Of Protein Kinase A Signaling Negative Regulation Of Mitochondrion Organization Sensory Perception Of Pain Negative Regulation Of Protein Complex Assembly Eating Behavior Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Cellular Protein Metabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Bone Resorption Positive Regulation Of Protein Kinase B Signaling Amylin Receptor Signaling Pathway Negative Regulation Of Amyloid Fibril Formation	Axonogenesis Involved In Innervation
Pathways		Regulation of gene expression in beta cells G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production Amyloid fiber formation	Collagen degradation Collagen biosynthesis and modifying enzymes Collagen chain trimerization
Drugs		Copper
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132)	Body mass index ( 25133637) Carotid plaque burden ( 28282560) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Height ( 28552196) Late-onset Alzheimer's disease ( 27770636) Schizophrenia (age at onset) ( 21688384) Systemic lupus erythematosus ( 21408207)
Interacting Genes		6 interacting genes: COL25A1 PCSK1 PCSK2 PDX1 RAMP1 RAMP2	3 interacting genes: APP IAPP SNCA
Entrez ID		3375	84570
HPRD ID		01005	09886
Ensembl ID		ENSG00000121351	ENSG00000188517
Uniprot IDs		A0A024RAU1 P10997	A0A2R8Y760 A8MWQ5 Q9BXS0
PDB IDs		1KUW 2G48 2KB8 2L86 3DG1 3FPO 3FR1 3FTH 3FTK 3FTL 3FTR 3G7V 3G7W 3HGZ 5K5G 5KNZ 5KO0 5MGQ
Enriched GO Terms of Interacting Partners?
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