IAPP and PCSK2

Number of citations of the paper that reports this interaction (PubMedID 3053705)
41

Data Source:
HPRD (in vitro, in vivo)

		IAPP	PCSK2
Description		islet amyloid polypeptide	proprotein convertase subtilisin/kexin type 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Neuronal Cell Body	Extracellular Space Nucleoplasm Trans-Golgi Network Membrane Transport Vesicle Secretory Granule Integral Component Of Golgi Membrane Dendrite Perikaryon Intracellular Membrane-bounded Organelle
	Molecular Function	Amyloid-beta Binding Signaling Receptor Binding Hormone Activity Protein Binding Identical Protein Binding	Serine-type Endopeptidase Activity Protein Binding Protein-containing Complex Binding
	Biological Process	Apoptotic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Positive Regulation Of Protein Kinase A Signaling Negative Regulation Of Mitochondrion Organization Sensory Perception Of Pain Negative Regulation Of Protein Complex Assembly Eating Behavior Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Cellular Protein Metabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Bone Resorption Positive Regulation Of Protein Kinase B Signaling Amylin Receptor Signaling Pathway Negative Regulation Of Amyloid Fibril Formation	Proteolysis Nervous System Development Protein Processing Peptide Hormone Processing Protein Autoprocessing Insulin Processing Enkephalin Processing Islet Amyloid Polypeptide Processing
Pathways		Regulation of gene expression in beta cells G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production Amyloid fiber formation	Insulin processing
Drugs		Copper	Insulin Human Insulin Pork
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132)	Biochemical measures ( 19260141) Chronotype ( 30696823) Dialysis-related mortality ( 21546767) Familial lung cancer ( 29924316) Loneliness ( 27629369) Menarche (age at onset) ( 21102462 25231870) Morning person ( 30696823) Obesity-related traits ( 23251661) Preschool internalizing problems ( 24839885) Response to fenofibrate (triglyceride levels) ( 27002377)
Interacting Genes		6 interacting genes: COL25A1 PCSK1 PCSK2 PDX1 RAMP1 RAMP2	3 interacting genes: IAPP PMCH SCG5
Entrez ID		3375	5126
HPRD ID		01005	01202
Ensembl ID		ENSG00000121351	ENSG00000125851
Uniprot IDs		A0A024RAU1 P10997	P16519
PDB IDs		1KUW 2G48 2KB8 2L86 3DG1 3FPO 3FR1 3FTH 3FTK 3FTL 3FTR 3G7V 3G7W 3HGZ 5K5G 5KNZ 5KO0 5MGQ
Enriched GO Terms of Interacting Partners?
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