JAGN1 and CLEC7A

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		JAGN1	CLEC7A
Description		jagunal homolog 1	C-type lectin domain containing 7A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Cytoplasm Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	Protein Binding	(1->3)-beta-D-glucan Binding Protein Binding Carbohydrate Binding Pattern Recognition Receptor Activity MHC Protein Binding Metal Ion Binding
	Biological Process	Neutrophil Mediated Immunity Exocytosis Endoplasmic Reticulum Organization Protein Transport Vesicle-mediated Transport Neutrophil Differentiation Granulocyte Colony-stimulating Factor Signaling Pathway Defense Response To Fungus Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cellular Response To Tunicamycin Neutrophil Migration	Phagocytosis, Recognition Inflammatory Response Cell Recognition Positive Regulation Of Cell Proliferation Carbohydrate Mediated Signaling Positive Regulation Of Gene Expression Detection Of Fungus Positive Regulation Of Cell Migration Positive Regulation Of Protein Complex Assembly Detection Of Molecule Of Fungal Origin Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Superoxide Anion Generation T Cell Activation Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Defense Response To Protozoan Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Interferon-gamma Biosynthetic Process Positive Regulation Of Interleukin-10 Biosynthetic Process Positive Regulation Of Interleukin-12 Biosynthetic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Positive Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Phagocytosis Positive Regulation Of Lymphocyte Activation Positive Regulation Of Killing Of Cells Of Other Organism Positive Regulation Of Respiratory Burst Cellular Response To Molecule Of Fungal Origin Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of Wound Healing Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Cell Maturation
Pathways			CLEC7A (Dectin-1) signaling CLEC7A (Dectin-1) signaling
Drugs
Diseases			Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS
Interacting Genes		6 interacting genes: APP CLEC7A CREB3L1 KASH5 LMNA VKORC1	19 interacting genes: ADAM33 AIP BNIP3 BNIP3L CALM3 FAM3A HSPD1 IL1RL1 JAGN1 KTN1 NINJ2 OCLN PTTG1IP RANBP9 RHOU SMIM3 SYNE4 TMEM79 TMPRSS4
Entrez ID		84522	64581
HPRD ID		13749	08396
Ensembl ID		ENSG00000171135	ENSG00000172243
Uniprot IDs		Q8N5M9	A0A024RAN9 A0A0S2Z5Q1 Q68D78 Q9BXN2
PDB IDs
Enriched GO Terms of Interacting Partners?
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