CLEC7A and KTN1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		CLEC7A	KTN1
Description		C-type lectin domain containing 7A	kinectin 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Surface Integral Component Of Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	(1->3)-beta-D-glucan Binding Protein Binding Carbohydrate Binding Pattern Recognition Receptor Activity MHC Protein Binding Metal Ion Binding	RNA Binding Protein Binding Kinesin Binding Cadherin Binding
	Biological Process	Phagocytosis, Recognition Inflammatory Response Cell Recognition Positive Regulation Of Cell Proliferation Carbohydrate Mediated Signaling Positive Regulation Of Gene Expression Detection Of Fungus Positive Regulation Of Cell Migration Positive Regulation Of Protein Complex Assembly Detection Of Molecule Of Fungal Origin Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Superoxide Anion Generation T Cell Activation Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Defense Response To Protozoan Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Interferon-gamma Biosynthetic Process Positive Regulation Of Interleukin-10 Biosynthetic Process Positive Regulation Of Interleukin-12 Biosynthetic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Positive Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Phagocytosis Positive Regulation Of Lymphocyte Activation Positive Regulation Of Killing Of Cells Of Other Organism Positive Regulation Of Respiratory Burst Cellular Response To Molecule Of Fungal Origin Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of Wound Healing Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Cell Maturation	Microtubule-based Movement Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		CLEC7A (Dectin-1) signaling CLEC7A (Dectin-1) signaling	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate KTN1 Post-translational protein phosphorylation
Drugs
Diseases		Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS			Early spontaneous preterm birth ( 31194736) Lean body mass ( 28552196) Neurofibrillary tangles ( 31497858) Plasma anti-thyroglobulin levels ( 29678681) Subcortical brain region volumes ( 25607358)
Interacting Genes		19 interacting genes: ADAM33 AIP BNIP3 BNIP3L CALM3 FAM3A HSPD1 IL1RL1 JAGN1 KTN1 NINJ2 OCLN PTTG1IP RANBP9 RHOU SMIM3 SYNE4 TMEM79 TMPRSS4	14 interacting genes: BNIP3 CDC42 CLEC7A EEF1D IKBKE KIF5B MEOX2 PLEKHA5 RAC1 RHOA RHOG SGTA SIRPA SYNE4
Entrez ID		64581	3895
HPRD ID		08396	02661
Ensembl ID		ENSG00000172243	ENSG00000126777
Uniprot IDs		A0A024RAN9 A0A0S2Z5Q1 Q68D78 Q9BXN2	A0A024R663 Q86UP2
PDB IDs
Enriched GO Terms of Interacting Partners?
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