MCM10 and NINL

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (two hybrid, proximity labelling technology)
HPRD (two hybrid)

		MCM10	NINL
Description		minichromosome maintenance 10 replication initiation factor	ninein like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Replication Fork Protection Complex	Centrosome Cytosol Microtubule Intercellular Bridge
	Molecular Function	DNA Replication Origin Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding Enzyme Binding Identical Protein Binding Metal Ion Binding	Calcium Ion Binding Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Cellular Response To DNA Damage Stimulus Cell Proliferation	G2/M Transition Of Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Microtubule Anchoring At Centrosome Ciliary Basal Body-plasma Membrane Docking
Pathways		Activation of ATR in response to replication stress Activation of the pre-replicative complex	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS			Macular thickness ( 30535121) Telomere length ( 30185882) Urate levels ( 31578528)
Interacting Genes		35 interacting genes: APP CALCOCO2 CCDC85B CCND1 CCND3 CDC45 CDC5L CDC6 CDC7 CDK6 CDKN1A CDKN2A CEP70 CEP72 DAPK1 DPPA2 GOLGA2 HAUS1 HOOK2 IKBKG KRT15 MCM2 MCM3 MCM6 MCM7 NINL ORC2 ORC3 ORC4 RECQL4 TNIP1 TRIM37 YWHAE ZBTB43 ZBTB8A	50 interacting genes: AKAP17A APEX2 APMAP AURKB CBY2 CCDC130 CCDC146 CCDC33 CCHCR1 CLEC1B DCTN5 ELOA EWSR1 EZH2 FAM107A FAM161A GCC1 GPKOW HAUS1 JUNB KANSL1 KAT5 KAT7 KRT1 L3MBTL4 LRSAM1 LZTS2 MAD1L1 MBIP MCM10 PLK1 POLR3F RBM41 RCOR3 RGS2 RIBC2 SEC23B SH2D4A SH3BP5L SYT17 TCEANC TNNT1 TSPYL4 UTP14A ZFC3H1 ZFHX3 ZNF250 ZNF417 ZNF426 ZNF646
Entrez ID		55388	22981
HPRD ID		11297	11120
Ensembl ID		ENSG00000065328	ENSG00000101004
Uniprot IDs		Q7L590	Q9Y2I6
PDB IDs
Enriched GO Terms of Interacting Partners?
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