CAPZA1 and SH3KBP1

Number of citations of the paper that reports this interaction (PubMedID 28514442)
199

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		CAPZA1	SH3KBP1
Description		capping actin protein of muscle Z-line subunit alpha 1	SH3 domain containing kinase binding protein 1
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GO Annotations	Cellular Component	Extracellular Region Cytosol Cytoskeleton F-actin Capping Protein Complex Actin Cytoskeleton Actin Cortical Patch Extracellular Exosome WASH Complex	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Endocytic Vesicle Cytoplasmic Vesicle Membrane Neuron Projection Synapse
	Molecular Function	Actin Binding Protein Binding Cadherin Binding Actin Filament Binding	Protein Binding SH3 Domain Binding
	Biological Process	ER To Golgi Vesicle-mediated Transport Blood Coagulation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Actin Cytoskeleton Organization Cell Junction Assembly Interleukin-12-mediated Signaling Pathway Innate Immune Response Barbed-end Actin Filament Capping Protein-containing Complex Assembly	Endocytosis Apoptotic Process Cytoskeleton Organization Actin Filament Organization Cell-cell Signaling Axon Guidance Regulation Of Cell Shape Cell Migration Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of B Cell Activation Membrane Organization
Pathways		MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Advanced glycosylation endproduct receptor signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production	EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Reelin signalling pathway InlB-mediated entry of Listeria monocytogenes into host cell Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
GWAS		Blood pressure ( 21572416) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chronotype ( 30696823) Diastolic blood pressure ( 26390057 27841878 28739976 27618452 30487518) Height ( 25282103) Hypertension ( 30487518) Intraocular pressure ( 29617998 29785010) Mean arterial pressure ( 30487518) Platelet count ( 27863252) Systolic blood pressure ( 27841878 28739976 27618452 30487518) Total cholesterol levels ( 30275531)
Interacting Genes		7 interacting genes: ACTB CD2AP HSPA8 S100A1 S100B SH3KBP1 UCHL5	44 interacting genes: ABI2 ARAP3 ARHGAP27 ASAP1 ASAP2 BCAR1 BLNK BMPR1B CAPZA1 CBL CBLB CD2 GRB2 HCK INPP5D ITSN2 MVB12A NEDD4 PAK2 PDCD6 PDCD6IP PIK3CA PIK3R1 PNMA5 PSMA3 SEPTIN2 SEPTIN6 SH3BP2 SH3GL2 SH3GL3 SH3GLB1 SH3GLB2 SHKBP1 SOS1 SPRY2 STAP1 SYNJ1 TAF6 TJP2 UBB UBC UBE2I ZBTB7B ZNF219
Entrez ID		829	30011
HPRD ID		03347	02301
Ensembl ID		ENSG00000116489	ENSG00000147010
Uniprot IDs		P52907	B7Z6E8 Q5JPT6 Q96B97
PDB IDs		1MQ1 1MWN	2BZ8 2K6D 2K9G 2N64 2O2O 2YDL 5ABS
Enriched GO Terms of Interacting Partners?
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