ARID1A and HIC1

Number of citations of the paper that reports this interaction (PubMedID 19486893)
20

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		ARID1A	HIC1
Description		AT-rich interaction domain 1A	HIC ZBTB transcriptional repressor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm SWI/SNF Complex Brahma Complex NpBAF Complex NBAF Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding Nuclear Receptor Binding Nucleosome Binding	DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Formation Of Primary Germ Layer Neural Tube Closure Cardiac Chamber Development Optic Cup Formation Involved In Camera-type Eye Development Nucleosome Disassembly Chromatin Remodeling Maintenance Of Chromatin Silencing Regulation Of Transcription By RNA Polymerase II Embryo Implantation Stem Cell Population Maintenance Intracellular Estrogen Receptor Signaling Pathway Androgen Receptor Signaling Pathway Forebrain Development Nucleosome Mobilization Glucocorticoid Receptor Signaling Pathway ATP-dependent Chromatin Remodeling Positive Regulation Of Transcription, DNA-templated Chromatin-mediated Maintenance Of Transcription Cardiac Muscle Cell Differentiation Placenta Blood Vessel Development Toxin Transport	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Multicellular Organism Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	SUMOylation of transcription factors
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549 28869591) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Metabolic syndrome ( 31589552) Monocyte percentage of white cells ( 27863252) Rosacea symptom severity ( 29771307) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) White matter hyperintensities in ischemic stroke ( 26674333)	Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Platelet count ( 27863252) Plateletcrit ( 27863252)
Interacting Genes		17 interacting genes: ESR1 EWSR1 FUS GATA1 HIC1 ITCH KLF1 MLLT1 NCOA1 NEDD4 PGR RARA RARB RARG SMARCA4 TAF15 TP53	12 interacting genes: ARID1A CRBN CTBP1 CTBP2 HDAC1 HIC2 MECOM PIAS1 SENP3 SIRT1 TCF7L2 UBE2I
Entrez ID		8289	3090
HPRD ID		04319	04826
Ensembl ID		ENSG00000117713	ENSG00000177374
Uniprot IDs		O14497	A0PJI1 Q14526
PDB IDs		1RYU
Enriched GO Terms of Interacting Partners?
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