HIC1 and SENP3

Number of citations of the paper that reports this interaction (PubMedID 17283066)
59

Data Source:
BioGRID (enzymatic study)

		HIC1	SENP3
Description		HIC ZBTB transcriptional repressor 1	SUMO specific peptidase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Nucleus Nucleoplasm Nucleolus Cytoplasm MLL1 Complex
	Molecular Function	DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding	Protein Binding Cysteine-type Peptidase Activity SUMO-specific Protease Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Multicellular Organism Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator	RRNA Processing Protein Desumoylation
Pathways		SUMOylation of transcription factors	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Platelet count ( 27863252) Plateletcrit ( 27863252)	IgM levels ( 23118916)
Interacting Genes		12 interacting genes: ARID1A CRBN CTBP1 CTBP2 HDAC1 HIC2 MECOM PIAS1 SENP3 SIRT1 TCF7L2 UBE2I	15 interacting genes: ATF7IP CDCA8 CDK4 CDK6 DNM1L EP300 HIC1 MDM2 NPM1 PARP1 SUMO2 TRIM54 TRIM63 USP15 USP21
Entrez ID		3090	26168
HPRD ID		04826	08339
Ensembl ID		ENSG00000177374	ENSG00000161956
Uniprot IDs		A0PJI1 Q14526	Q9H4L4
PDB IDs
Enriched GO Terms of Interacting Partners?
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