ADAM33 and CLEC7A

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ADAM33	CLEC7A
Description		ADAM metallopeptidase domain 33	C-type lectin domain containing 7A
Image			No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane	Cytoplasm Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	Metalloendopeptidase Activity Zinc Ion Binding	(1->3)-beta-D-glucan Binding Protein Binding Carbohydrate Binding Pattern Recognition Receptor Activity MHC Protein Binding Metal Ion Binding
	Biological Process	Proteolysis	Phagocytosis, Recognition Inflammatory Response Cell Recognition Positive Regulation Of Cell Proliferation Carbohydrate Mediated Signaling Positive Regulation Of Gene Expression Detection Of Fungus Positive Regulation Of Cell Migration Positive Regulation Of Protein Complex Assembly Detection Of Molecule Of Fungal Origin Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Superoxide Anion Generation T Cell Activation Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Defense Response To Protozoan Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Interferon-gamma Biosynthetic Process Positive Regulation Of Interleukin-10 Biosynthetic Process Positive Regulation Of Interleukin-12 Biosynthetic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Positive Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Phagocytosis Positive Regulation Of Lymphocyte Activation Positive Regulation Of Killing Of Cells Of Other Organism Positive Regulation Of Respiratory Burst Cellular Response To Molecule Of Fungal Origin Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of Wound Healing Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Cell Maturation
Pathways			CLEC7A (Dectin-1) signaling CLEC7A (Dectin-1) signaling
Drugs
Diseases		Asthma	Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS		Night sleep phenotypes ( 27126917)
Interacting Genes		5 interacting genes: ATXN7 CLEC7A LMNA SLC30A2 UBQLN4	19 interacting genes: ADAM33 AIP BNIP3 BNIP3L CALM3 FAM3A HSPD1 IL1RL1 JAGN1 KTN1 NINJ2 OCLN PTTG1IP RANBP9 RHOU SMIM3 SYNE4 TMEM79 TMPRSS4
Entrez ID		80332	64581
HPRD ID		06173	08396
Ensembl ID		ENSG00000149451	ENSG00000172243
Uniprot IDs		A2A2L3 Q9BZ11	A0A024RAN9 A0A0S2Z5Q1 Q68D78 Q9BXN2
PDB IDs		1R54 1R55
Enriched GO Terms of Interacting Partners?
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