DBF4B and CDC7

Number of citations of the paper that reports this interaction (PubMedID 12065429)
28

Data Source:
HPRD (in vivo, in vitro)

		DBF4B	CDC7
Description		DBF4 zinc finger B	cell division cycle 7
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Aggresome Dbf4-dependent Protein Kinase Complex Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Intercellular Bridge Mitotic Spindle
	Molecular Function	Nucleic Acid Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Kinase Activator Activity Protein Serine/threonine Kinase Activator Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Metal Ion Binding
	Biological Process	Cell Cycle Positive Regulation Of Cell Proliferation Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Phase Transition	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Positive Regulation Of Cell Proliferation Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Cell Cycle Phase Transition Cell Division Negative Regulation Of G0 To G1 Transition
Pathways			Activation of ATR in response to replication stress Activation of the pre-replicative complex Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS			Eosinophil percentage of white cells ( 27863252) Gestational age at birth (maternal effect) ( 28877031) Glaucoma (primary open-angle) ( 25861811) Lung function (FEV1/FVC) ( 28166213) Lung function (FVC) ( 26635082) Optic disc area ( 25631615 31798171 28073927 21307088) Optic disc parameters ( 20548946) Optic disc size ( 31809533) Optic nerve measurement (cup-to-disc ratio) ( 28061514) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Vertical cup-disc ratio ( 31798171 25241763 28073927) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		8 interacting genes: CDC7 KDM1A KRTAP4-12 LMO2 LRRK2 MDFI SRPK2 SUV39H1	26 interacting genes: APP CDK2 CDK4 CDK9 CDKN1A CDKN2A CHAF1A CLSPN CSDE1 DBF4 DBF4B DIAPH1 DTD1 GPT GRHPR MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC5 ORC6 TOB1
Entrez ID		80174	8317
HPRD ID		16840	10345
Ensembl ID		ENSG00000161692	ENSG00000097046
Uniprot IDs		Q8NFT6	A0A384MTU6 B2R6V2 O00311
PDB IDs			4F99 4F9A 4F9B 4F9C 5UWQ 5UWR
Enriched GO Terms of Interacting Partners?
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