NR4A3 and SIX3

Number of citations of the paper that reports this interaction (PubMedID 12543801)
11

Data Source:
BioGRID (two hybrid)
HPRD (in vivo, in vitro)

		NR4A3	SIX3
Description		nuclear receptor subfamily 4 group A member 3	SIX homeobox 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Mast Cell Granule	Nuclear Chromatin Nucleus Transcription Factor Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Histone Acetyltransferase Binding Glucocorticoid Receptor Binding CAMP Response Element Binding Protein Homodimerization Activity Sequence-specific DNA Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Coactivator Activity Signaling Receptor Binding Protein Binding Histone Deacetylase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mesoderm Formation Transcription Initiation From RNA Polymerase II Promoter Gastrulation Axon Guidance Pyruvate Oxidation Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Glucose Transmembrane Transport Hippocampus Development Intracellular Receptor Signaling Pathway Adult Behavior Animal Organ Regeneration Positive Regulation Of Mast Cell Cytokine Production Common Myeloid Progenitor Cell Proliferation Positive Regulation Of Mast Cell Activation By Fc-epsilon Receptor Signaling Pathway Response To Hydrogen Peroxide Mast Cell Degranulation Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Cellular Response To Leptin Stimulus Cellular Respiration Fat Cell Differentiation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fatty Acid Oxidation Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Semicircular Canal Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Neuromuscular Process Controlling Balance Vestibular Reflex Regulation Of Type B Pancreatic Cell Proliferation Cellular Response To Corticotropin-releasing Hormone Stimulus Cellular Response To Catecholamine Stimulus Energy Homeostasis Positive Regulation Of Monocyte Aggregation Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Feeding Behavior	Eye Development Epithelial Cell Maturation Lens Development In Camera-type Eye Optic Vesicle Morphogenesis Protein Import Into Nucleus Brain Development Visual Perception Proximal/distal Axis Specification Neuroblast Differentiation Telencephalon Development Forebrain Anterior/posterior Pattern Specification Forebrain Dorsal/ventral Pattern Formation Cell Proliferation In Forebrain Telencephalon Regionalization Pituitary Gland Development Negative Regulation Of Wnt Signaling Pathway Regulation Of Cell Proliferation Negative Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Circadian Behavior Anatomical Structure Development Lens Induction In Camera-type Eye Regulation Of Neural Retina Development Lens Fiber Cell Differentiation Neuroblast Migration Regulation Of Cell Cycle Phase Transition Regulation Of Neuroblast Proliferation Apoptotic Process Involved In Development Lens Fiber Cell Apoptotic Process Regulation Of Neural Precursor Cell Proliferation
Pathways		RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs		Dasatinib
Diseases		Extraskeletal myxoid chondrosarcoma	Holoprosencephaly (HPE)
GWAS		Dental caries ( 23064961) Depression in smokers ( 30219690) Lung cancer ( 28604730)	Adventurousness ( 30643258) Alcohol and nicotine co-dependence ( 22488850) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258 30679032) Alcohol use disorder ( 30940813) Blood sugar levels ( 29403010) Fasting blood glucose ( 29621232) Fasting plasma glucose ( 25187374) General risk tolerance (MTAG) ( 30643258) Glycated hemoglobin levels ( 29170429) Hemoglobin A1c levels ( 29403010) Intraocular pressure ( 29785010 31959993 30054594) Irritable mood ( 29500382) Lung cancer ( 28604730) Metabolite levels ( 21909109) Myopia ( 27182965) Optic disc size ( 31809533) Risk-taking tendency (4-domain principal component model) ( 30643258) Self-reported risk-taking behaviour ( 30271922) Smoking behaviour (cigarette pack-years) ( 30679032) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		5 interacting genes: COPS5 RPS6KA1 SIX3 TRIM28 VHL	7 interacting genes: EYA1 GMNN NR4A3 PAX6 TLE1 TLE3 TLE5
Entrez ID		8013	6496
HPRD ID		02766	04756
Ensembl ID		ENSG00000119508	ENSG00000138083
Uniprot IDs		A0A024R168 Q92570	O95343
PDB IDs
Enriched GO Terms of Interacting Partners?
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