SIX3

Description		SIX homeobox 3
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Transcription Factor Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Coactivator Activity Signaling Receptor Binding Protein Binding Histone Deacetylase Binding
	Biological Process	Eye Development Epithelial Cell Maturation Lens Development In Camera-type Eye Optic Vesicle Morphogenesis Protein Import Into Nucleus Brain Development Visual Perception Proximal/distal Axis Specification Neuroblast Differentiation Telencephalon Development Forebrain Anterior/posterior Pattern Specification Forebrain Dorsal/ventral Pattern Formation Cell Proliferation In Forebrain Telencephalon Regionalization Pituitary Gland Development Negative Regulation Of Wnt Signaling Pathway Regulation Of Cell Proliferation Negative Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Circadian Behavior Anatomical Structure Development Lens Induction In Camera-type Eye Regulation Of Neural Retina Development Lens Fiber Cell Differentiation Neuroblast Migration Regulation Of Cell Cycle Phase Transition Regulation Of Neuroblast Proliferation Apoptotic Process Involved In Development Lens Fiber Cell Apoptotic Process Regulation Of Neural Precursor Cell Proliferation
Pathways
Drugs
Diseases		Holoprosencephaly (HPE)
GWAS		Adventurousness ( 30643258) Alcohol and nicotine co-dependence ( 22488850) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258 30679032) Alcohol use disorder ( 30940813) Blood sugar levels ( 29403010) Fasting blood glucose ( 29621232) Fasting plasma glucose ( 25187374) General risk tolerance (MTAG) ( 30643258) Glycated hemoglobin levels ( 29170429) Hemoglobin A1c levels ( 29403010) Intraocular pressure ( 29785010 31959993 30054594) Irritable mood ( 29500382) Lung cancer ( 28604730) Metabolite levels ( 21909109) Myopia ( 27182965) Optic disc size ( 31809533) Risk-taking tendency (4-domain principal component model) ( 30643258) Self-reported risk-taking behaviour ( 30271922) Smoking behaviour (cigarette pack-years) ( 30679032) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		7 interacting genes: EYA1 GMNN NR4A3 PAX6 TLE1 TLE3 TLE5
Entrez ID		6496
HPRD ID		04756
Ensembl ID		ENSG00000138083
Uniprot IDs		O95343
PDB IDs
Enriched GO Terms of Interacting Partners?
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