NR4A3 and RPS6KA1

Number of citations of the paper that reports this interaction (PubMedID 16223362)
26

Data Source:
HPRD (in vivo)

		NR4A3	RPS6KA1
Description		nuclear receptor subfamily 4 group A member 3	ribosomal protein S6 kinase A1
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Mast Cell Granule	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Histone Acetyltransferase Binding Glucocorticoid Receptor Binding CAMP Response Element Binding Protein Homodimerization Activity Sequence-specific DNA Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mesoderm Formation Transcription Initiation From RNA Polymerase II Promoter Gastrulation Axon Guidance Pyruvate Oxidation Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Glucose Transmembrane Transport Hippocampus Development Intracellular Receptor Signaling Pathway Adult Behavior Animal Organ Regeneration Positive Regulation Of Mast Cell Cytokine Production Common Myeloid Progenitor Cell Proliferation Positive Regulation Of Mast Cell Activation By Fc-epsilon Receptor Signaling Pathway Response To Hydrogen Peroxide Mast Cell Degranulation Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Cellular Response To Leptin Stimulus Cellular Respiration Fat Cell Differentiation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fatty Acid Oxidation Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Semicircular Canal Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Neuromuscular Process Controlling Balance Vestibular Reflex Regulation Of Type B Pancreatic Cell Proliferation Cellular Response To Corticotropin-releasing Hormone Stimulus Cellular Response To Catecholamine Stimulus Energy Homeostasis Positive Regulation Of Monocyte Aggregation Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Feeding Behavior	Protein Phosphorylation Apoptotic Process Cell Cycle Signal Transduction Positive Regulation Of Cell Growth Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Translation In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Hepatocyte Proliferation Positive Regulation Of Hepatic Stellate Cell Activation
Pathways		RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK
Drugs		Dasatinib	Purvalanol A
Diseases		Extraskeletal myxoid chondrosarcoma
GWAS		Dental caries ( 23064961) Depression in smokers ( 30219690) Lung cancer ( 28604730)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Glucose homeostasis traits ( 25524916) Mean corpuscular volume ( 27863252) Rosacea symptom severity ( 29771307) Triglyceride levels ( 30108155)
Interacting Genes		5 interacting genes: COPS5 RPS6KA1 SIX3 TRIM28 VHL	86 interacting genes: ARHGEF11 ARHGEF12 ATXN3 BAD CARHSP1 CCT4 CDKN1B CEBPB CFL1 CREB1 CREBBP DDAH2 DEPTOR DLC1 DLG4 EEF1D EEF2K ERBIN ESR1 ETV1 FGFR1 FOS GBP2 GMFB GOPC GORASP1 GORASP2 GRB2 GRID2IP GSK3B HTRA1 L1CAM LIMK2 LNX1 MAGI1 MAGI2 MAGI3 MAPK1 MAPK3 MAPT MAST1 MAST2 METTL1 MITF MPP1 MTOR MXD1 NFKBIA NR4A1 NR4A2 NR4A3 PARD3B PDCD4 PDPK1 PDZD7 PDZK1 PDZRN3 PDZRN4 PHAX POLDIP3 PPM1G PPP1R3A PPP1R9A PTPN3 RPTOR SHANK3 SHROOM2 SLC9A3R2 SNTA1 SNTB1 SNTG2 SNX27 SRF SRSF5 SYK SYNJ2BP TAMALIN TOB2 TP53 TSC2 TTK UBE2T VCP WHRN YBX1 YWHAB
Entrez ID		8013	6195
HPRD ID		02766	03402
Ensembl ID		ENSG00000119508	ENSG00000117676
Uniprot IDs		A0A024R168 Q92570	Q15418
PDB IDs			2WNT 2Z7Q 2Z7R 2Z7S 3RNY 3TEI 4H3P 4NIF 5CSF 5CSI 5CSJ 5CSN 5N7D 5N7F 5N7G 5V61 5V62
Enriched GO Terms of Interacting Partners?
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