ARHGEF5 and COG6

Number of citations of the paper that reports this interaction (PubMedID 27107012)
28

Data Source:
BioGRID (two hybrid)

		ARHGEF5	COG6
Description		Rho guanine nucleotide exchange factor 5	component of oligomeric golgi complex 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell Junction Cell Projection Cell Periphery	Golgi Membrane Golgi Transport Complex Trans-Golgi Network Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Lipid Binding	Protein Binding
	Biological Process	Myeloid Dendritic Cell Chemotaxis G Protein-coupled Receptor Signaling Pathway Actin Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Positive Regulation Of JUN Kinase Activity Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Podosome Assembly Positive Regulation Of Protein Import	ER To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Protein Transport Glycosylation
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events	COPI-mediated anterograde transport Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		Breast cancer ( 23535729) Post bronchodilator FEV1/FVC ratio ( 26634245)	Asthma ( 30929738) Asthma (adult onset) ( 30929738) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Height ( 31562340) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Menarche (age at onset) ( 25231870) Multiple sclerosis ( 31604244 24076602) Neutrophil percentage of granulocytes ( 27863252) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Psoriasis ( 25903422 18369459) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031)
Interacting Genes		16 interacting genes: APP ATP13A1 CALCOCO2 CCNE1 CHPF COG6 CRKL EFHC2 FKBP8 HSPBAP1 NR4A1 PLCG1 SEPHS2 SLU7 TRIM27 TRIM54	17 interacting genes: ARHGEF5 ATXN7 BCL10 CCDC92 CCHCR1 CNN1 FAM90A1 FANCG GOLGA2 GRAP2 LGALS14 MCM7 NDUFA5 NTAQ1 RAB6B SCNM1 ZBTB16
Entrez ID		7984	57511
HPRD ID		02932	08445
Ensembl ID		ENSG00000050327	ENSG00000133103
Uniprot IDs		Q12774	A0A024RDW5 A0A140VJG7 Q9Y2V7
PDB IDs
Enriched GO Terms of Interacting Partners?
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